TGF-β and the TGF-β family: context-dependent roles in cell and tissue physiology

M Morikawa, R Derynck… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
The transforming growth factor-β (TGF-β) is the prototype of the TGF-β family of growth and
differentiation factors, which is encoded by 33 genes in mammals and comprises homo-and …

Bone physiology as inspiration for tissue regenerative therapies

D Lopes, C Martins-Cruz, MB Oliveira, JF Mano - Biomaterials, 2018 - Elsevier
The development, maintenance of healthy bone and regeneration of injured tissue in the
human body comprise a set of intricate and finely coordinated processes. However, an …

Bone morphogenetic proteins

T Katagiri, T Watabe - Cold Spring Harbor Perspectives …, 2016 - cshperspectives.cshlp.org
Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Structural biology and evolution of the TGF-β family

AP Hinck, TD Mueller… - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
We review the evolution and structure of members of the transforming growth factor β (TGF-
β) family, antagonistic or agonistic modulators, and receptors that regulate TGF-β signaling …

Endocrine role of bone in the regulation of energy metabolism

R Zhou, Q Guo, Y Xiao, Q Guo, Y Huang, C Li, X Luo - Bone research, 2021 - nature.com
Abstracts Bone mainly functions as a supportive framework for the whole body and is the
major regulator of calcium homeostasis and hematopoietic function. Recently, an increasing …

Bone morphogenetic protein receptor signal transduction in human disease

MC Gomez‐Puerto, PV Iyengar… - The journal of …, 2019 - Wiley Online Library
Bone morphogenetic proteins (BMPs) are secreted cytokines that were initially discovered
on the basis of their ability to induce bone. Several decades of research have now …

Oocyte–somatic cell interactions in the human ovary—novel role of bone morphogenetic proteins and growth differentiation factors

HM Chang, J Qiao, PCK Leung - Human reproduction update, 2017 - academic.oup.com
BACKGROUND Initially identified for their capability to induce heterotopic bone formation,
bone morphogenetic proteins (BMPs) are multifunctional growth factors that belong to the …

Bone morphogenetic proteins: a critical review

B Bragdon, O Moseychuk, S Saldanha, D King… - Cellular signalling, 2011 - Elsevier
Bone Morphogenetic Proteins (BMPs) are potent growth factors belonging to the
Transforming Growth Factor Beta superfamily. To date over 20 members have been …

Bone morphogenetic proteins

DI Chen, M Zhao, GR Mundy - Growth factors, 2004 - Taylor & Francis
Bone morphogenetic proteins (BMPs) are multi-functional growth factors that belong to the
transforming growth factor β (TGFβ) superfamily. The roles of BMPs in embryonic …

The BMP pathway and its inhibitors in the skeleton

JW Lowery, V Rosen - Physiological reviews, 2018 - journals.physiology.org
Bone morphogenetic proteins (BMPs) constitute the largest subdivision of the transforming
growth factor-β family of ligands. BMPs exhibit widespread utility and pleiotropic, context …