The multistep process of in vivo reprogramming, mediated by the transcription factors (TFs)
Oct4, Sox2, Klf4, and c-Myc (OSKM), holds great promise for the development of …

Phenotypic plasticity of cancer cells can lead to complex cell state dynamics during tumor
progression and acquired resistance. Highly plastic stem-like states may be inherently drug …

Single-cell transcriptome data has been widely used to reconstruct gene regulatory
networks (GRNs) controlling critical biological processes such as development and …

Organisms utilize gene regulatory networks (GRN) to make fate decisions, but the regulatory
mechanisms of transcription factors (TF) in GRNs are exceedingly intricate. A longstanding …

Correct nervous system development depends on the timely differentiation of progenitor
cells into neurons. While the output of progenitor differentiation is well investigated at the …

Highlights•Mechanisms of direct reprogramming highlight how cells maintain or change cell
fate.•Direct neuronal reprogramming shows advantages in modeling age-related …

Neuronal reprogramming is a promising approach for making major advancement in
regenerative medicine. Distinct from the approach of induced pluripotent stem cells …

Abstract Cleavage Under Targets and Release Using Nuclease (CUT&RUN) is an
increasingly popular technique to map genome-wide binding profiles of histone …

The sparse and stochastic nature of reprogramming has obscured our understanding of how
transcription factors drive cells to new identities. To overcome this limit, we developed a …

Dr. Pereira: Good afternoon. My name is Filipe Pereira, Professor at Lund University and
Editor-in-Chief of Cellular Reprogramming. I am very happy to bring you a new episode of …