Aging has been linked to several degenerative processes that, through the accumulation of
molecular and cellular damage, can progressively lead to cell dysfunction and organ failure …

Dietary polyphenols represent a wide variety of compounds that occur in fruits, vegetables,
wine, tea, extra virgin olive oil, chocolate and other cocoa products. They are mostly …

Abstract Sirtuins (SIRT1–SIRT7) are unique histone deacetylases (HDACs) whose activity
depends on NAD+ levels and thus on the cellular metabolic status. SIRTs regulate energy …

Introduction: Natural products have seen a wide range of acceptability for the prevention and
treatment of diseases throughout history. Resveratrol, a member of the stilbene family, has …

Mitochondria are highly dynamic organelles with complex structural features which play
several important cellular functions, such as the production of energy by oxidative …

Aging is the greatest risk factor for most diseases including cancer, cardiovascular disorders,
and neurodegenerative disease. There is emerging evidence that interventions that improve …

It is generally considered that Parkinson's disease is induced by specific agents that
degenerate a clearly defined population of dopaminergic neurons. Data commented in this …

Neurodegenerative diseases are characterized by the progressive loss of neurons in
different regions of the nervous system. Alzheimer's disease (AD) and Parkinson's disease …

Within the last years, a rapidly growing number of polyphenolic compounds with
neuroprotective effects have been described. Many efforts have been made to explore the …

Mitochondrial dysfunction and oxidative stress occur in Parkinson's disease (PD), but little is
known about the molecular mechanisms controlling these events. Peroxisome proliferator …