NAFLD in Asia—as common and important as in the West

GC Farrell, VWS Wong, S Chitturi - Nature reviews Gastroenterology & …, 2013 - nature.com
NAFLD—regarded as a consequence of the modern sedentary, food-abundant lifestyle
prevalent in the West—was recorded in Japan nearly 50 years ago and its changing …

The effect of PNPLA3 on fibrosis progression and development of hepatocellular carcinoma: a meta-analysis

AG Singal, H Manjunath, AC Yopp… - Official journal of the …, 2014 - journals.lww.com
OBJECTIVES: The PNPLA3 rs738409 single-nucleotide polymorphism is known to promote
nonalcoholic steatohepatitis (NASH), but its association with fibrosis severity and …

[HTML][HTML] Non-alcoholic fatty liver disease: what the clinician needs to know

MV Machado, H Cortez-Pinto - World journal of gastroenterology …, 2014 - ncbi.nlm.nih.gov
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of liver disease in the
Western world. Furthermore, it is increasing worldwide, paralleling the obesity pandemic …

Epidemiologic, genetic, pathogenic, metabolic, epigenetic aspects involved in NASH-HCC: current therapeutic strategies

J Gutiérrez-Cuevas, S Lucano-Landeros… - Cancers, 2022 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is an aggressive human cancer and is
caused as consequences of chronic liver diseases. Although HCC is more common in …

Pathogenesis of NASH: how metabolic complications of overnutrition favour lipotoxicity and pro-inflammatory fatty liver disease

GC Farrell, F Haczeyni, S Chitturi - Obesity, Fatty Liver and Liver Cancer, 2018 - Springer
Overnutrition, usually with obesity and genetic predisposition, lead to insulin resistance,
which is an invariable accompaniment of nonalcoholic fatty liver disease (NAFLD). The …

[HTML][HTML] Nonalcoholic fatty liver disease: a comprehensive review of a growing epidemic

K Hassan, V Bhalla, ME El Regal… - World journal of …, 2014 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) is quickly becoming one of the most prominent
causes of liver disease worldwide. The increasing incidence of NAFLD is tied to the obesity …

[HTML][HTML] Comparison between obese and non-obese nonalcoholic fatty liver disease

WK Chan - Clinical and Molecular Hepatology, 2023 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of liver conditions that
are characterized by excess accumulation of fat in the liver, and is diagnosed after exclusion …

Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers

T Kawaguchi, T Shima, M Mizuno, Y Mitsumoto… - PLoS …, 2018 - journals.plos.org
The genetic factors affecting the natural history of nonalcoholic fatty liver disease (NAFLD),
including the development of nonalcoholic steatohepatitis (NASH) and NASH-derived …

Association between PNPLA3 rs738409 polymorphism and nonalcoholic fatty liver disease (NAFLD) susceptibility and severity: A meta-analysis

G Dai, P Liu, X Li, X Zhou, S He - Medicine, 2019 - journals.lww.com
Objective: This meta-analysis is to investigate the relationship between the patatin-like
phospholipase domain containing 3 (PNPLA3) rs738409 polymorphism and the …

Nonalcoholic fatty liver disease: a global perspective

WK Wong, WK Chan - Clinical therapeutics, 2021 - Elsevier
The prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing over the
years and is now as high in Asia as in the Western world, so much so that it should no longer …