How RNA-binding proteins interact with RNA: molecules and mechanisms
M Corley, MC Burns, GW Yeo - Molecular cell, 2020 - cell.com
RNA-binding proteins (RBPs) comprise a large class of over 2,000 proteins that interact with
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
transcripts in all manner of RNA-driven processes. The structures and mechanisms that …
Tau post-translational modifications: dynamic transformers of tau function, degradation, and aggregation
C Alquezar, S Arya, AW Kao - Frontiers in neurology, 2021 - frontiersin.org
Post-translational modifications (PTMs) on tau have long been recognized as affecting
protein function and contributing to neurodegeneration. The explosion of information on …
protein function and contributing to neurodegeneration. The explosion of information on …
Functions and mechanisms of non-histone protein acetylation
N ε-lysine acetylation was discovered more than half a century ago as a post-translational
modification of histones and has been extensively studied in the context of transcription …
modification of histones and has been extensively studied in the context of transcription …
Past, present, and future perspectives of transcription factor EB (TFEB): mechanisms of regulation and association with disease
Transcription factor EB (TFEB), a member of the MiT/TFE family of basic helix-loop-helix
leucine zipper transcription factors, is an established central regulator of the …
leucine zipper transcription factors, is an established central regulator of the …
Epigenetic therapies for cancer
SE Bates - New England Journal of Medicine, 2020 - Mass Medical Soc
Epigenetic Therapies for Cancer | New England Journal of Medicine Skip to main content The
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
New England Journal of Medicine homepage Advanced Search SEARCH SPECIALTIES …
Specificity, versatility, and control of TGF-β family signaling
R Derynck, EH Budi - Science signaling, 2019 - science.org
Encoded in mammalian cells by 33 genes, the transforming growth factor–β (TGF-β) family
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
of secreted, homodimeric and heterodimeric proteins controls the differentiation of most, if …
Meta-inflammation and metabolic reprogramming of macrophages in diabetes and obesity: the importance of metabolites
S Russo, M Kwiatkowski, N Govorukhina… - Frontiers in …, 2021 - frontiersin.org
Diabetes mellitus type II and obesity are two important causes of death in modern society.
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …
They are characterized by low-grade chronic inflammation and metabolic dysfunction (meta …
[HTML][HTML] X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women
Although women experience significantly higher tau burden and increased risk for
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
Alzheimer's disease (AD) than men, the underlying mechanism for this vulnerability has not …
T cell stemness and dysfunction in tumors are triggered by a common mechanism
INTRODUCTION Cancers persist and progress despite the presence of tumor-infiltrating
lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …
lymphocytes (TILs). A paradox of tumor immunology is that tumor antigen–specific TILs are …
Metabolites as regulators of insulin sensitivity and metabolism
Q Yang, A Vijayakumar, BB Kahn - Nature reviews Molecular cell …, 2018 - nature.com
The cause of insulin resistance in obesity and type 2 diabetes mellitus (T2DM) is not limited
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …
to impaired insulin signalling but also involves the complex interplay of multiple metabolic …