Drosophila melanogaster provides a powerful genetic model system in which to investigate
the molecular mechanisms underlying neurodegenerative diseases. In this review, we …

Abstract Ubiquilin-2 (UBQLN2) is a member of the ubiquilin family, actively implicated in the
degradation of misfolded and redundant proteins through the ubiquitin-proteasome system …

The ubiquitin-like protein ubiquilin 2 (UBQLN2) has been genetically and pathologically
linked to the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and …

Alterations in autophagy and the ubiquitin proteasome system (UPS) are commonly
implicated in protein aggregation and toxicity which manifest in a number of neurological …

Proteasomal shuttle factor UBQLN2 is recruited to stress granules and undergoes liquid-
liquid phase separation (LLPS) into protein-containing droplets. Mutations to UBQLN2 have …

UBQLN2 is one of a family of proteins implicated in ubiquitin-dependent protein quality
control and integrally tied to human neurodegenerative disease. Whereas wild-type …

Ubiquilin (UBQLN) proteins are a dynamic and versatile family of proteins found in all
eukaryotes that function in the regulation of proteostasis. Besides their canonical function as …

Cells rely on protein homeostasis to maintain proper biological functions. Dysregulation of
protein homeostasis contributes to the pathogenesis of many neurodegenerative diseases …

Background and Objectives To perform the first screen of 44 amyotrophic lateral sclerosis
(ALS) genes in a cohort of African genetic ancestry individuals with ALS using whole …

Tau protein accumulation drives toxicity in several neurodegenerative disorders. To better
understand the pathways regulating tau homeostasis in disease, we investigated the role of …