Patterns are ubiquitous in living systems and underlie the dynamic organization of cells,
tissues, and embryos. Mathematical frameworks have been devised to account for the self …

Segmentation of the paraxial mesoderm is a major event of vertebrate development that
establishes the metameric patterning of the body axis. This process involves the periodic …

The segmented body plan of vertebrates is established during somitogenesis, a well-studied
process in model organisms; however, the details of this process in humans remain largely …

The vertebrate body displays a segmental organization that is most conspicuous in the
periodic organization of the vertebral column and peripheral nerves. This metameric …

Combining concepts from topology and algorithms, this book delivers what its title promises:
an introduction to the field of computational topology. Starting with motivating problems in …

Our knowledge of the principles by which organ architecture develops through complex
collective cell behaviours is still limited. Recent work has shown that the shape of such …

The segmental organization of the vertebral column is established early in embryogenesis,
when pairs of somites are rhythmically produced by the presomitic mesoderm (PSM). The …

Notch signaling dictates cell fate and critically influences cell proliferation, differentiation,
and apoptosis in metazoans. Multiple factors at each step—ligands, receptors, signal …

Notch is a transmembrane receptor that mediates local cell-cell communication and
coordinates a signaling cascade present in all animal species studied to date. Notch …

Axial development of mammals involves coordinated morphogenetic events, including axial
elongation, somitogenesis, and neural tube formation. To gain insight into the signals …