The present study aimed at investigating genetic variations, specific signal pathways, or
biological processes of chromosome 1 genes between subtypes and stages of lung cancer …

Background The frequent recurrence of early-stage non-small-cell lung cancer (NSCLC) is
generally attributable to metastatic disease undetected at complete resection. Management …

Preclinical evidence has been accumulating on the impact of the DNA repair status on the
sensitivity/resistance to anticancer agents in different tumor types, including lung cancer …

Matrix metalloproteinases (Mmps) stimulate tumor invasion and metastasis by degrading the
extracellular matrix. Here we reveal an unexpected role for Mmp10 (stromelysin 2) in the …

Background The malignancy-risk gene signature is composed of numerous proliferative
genes and has been applied to predict breast cancer risk. We hypothesized that the …

As a CXC-type chemokine, ENA78/CXCL5 is an important attractant for granulocytes by
binding to its receptor CXCR2. Recent studies proved that CXCL5/CXCR2 axis plays an …

Background: Interaction between cancer cells with microenvironment is essential for cancer
progression, therapeutic resistance and prognosis. Chemokine CXCL1 shows variable roles …

Background: Vascular endothelial growth factor A (VEGFA) and angiopoietin 2 (ANGPT2)
are key mediators in angiogenesis. The expression and clinical significance of VEGFA and …

Introduction: Gene expression profiling of non-small cell lung cancer (NSCLC) tissues let to
the establishment of several prognostic, predictive gene signatures with little overlap. To …

Lung cancer is the principal cause of leading cancer-related incidence and mortality in the
world. Various studies have excavated the potential prognostic biomarkers for cancer …