[HTML][HTML] SARS-CoV-2 variant biology: immune escape, transmission and fitness

AM Carabelli, TP Peacock, LG Thorne… - Nature Reviews …, 2023 - nature.com
In late 2020, after circulating for almost a year in the human population, severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) exhibited a major step change in its …

Antibody and B cell responses to SARS-CoV-2 infection and vaccination: the end of the beginning

K Röltgen, SD Boyd - Annual Review of Pathology: Mechanisms …, 2024 - annualreviews.org
As the COVID-19 pandemic has evolved during the past years, interactions between human
immune systems, rapidly mutating and selected SARS-CoV-2 viral variants, and effective …

Correlation between pseudotyped virus and authentic virus neutralisation assays, a systematic review and meta-analysis of the literature

D Cantoni, C Wilkie, EM Bentley… - Frontiers in …, 2023 - frontiersin.org
Background The virus neutralization assay is a principal method to assess the efficacy of
antibodies in blocking viral entry. Due to biosafety handling requirements of viruses …

Case report: Treatment of long COVID with a SARS-CoV-2 antiviral and IL-6 blockade in a patient with rheumatoid arthritis and SARS-CoV-2 antigen persistence

L Visvabharathy, ZS Orban, IJ Koralnik - Frontiers in Medicine, 2022 - frontiersin.org
Introduction Long COVID, or post-acute sequelae of SARS-CoV-2 infection (PASC) in∼
30% of all infected individuals. Here, we present a case of PASC in a patient with …

COVID-19 clinical features and outcomes in elderly patients during six pandemic waves

RM Fericean, O Rosca, C Citu, D Manolescu… - Journal of Clinical …, 2022 - mdpi.com
Many elderly patients with severe SARS-CoV-2 infections and COVID-19 infections are
admitted to intensive care units. Age was previously identified as an independent risk factor …

Tfh cells and the germinal center are required for memory B cell formation & humoral immunity after ChAdOx1 nCoV-19 vaccination

WS Foster, J Le Lee, N Thakur, J Newman… - Cell Reports …, 2022 - cell.com
Emergence from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
pandemic has been facilitated by the rollout of effective vaccines. Successful vaccines …

Cross-protective HCoV immunity reduces symptom development during SARS-CoV-2 infection

IA Abela, M Schwarzmüller, A Ulyte, T Radtke… - Mbio, 2024 - Am Soc Microbiol
Numerous clinical parameters link to severe coronavirus disease 2019, but factors that
prevent symptomatic disease remain unknown. We investigated the impact of severe acute …

Intradermal administration of DNA vaccine targeting Omicron SARS-CoV-2 via pyro-drive jet injector provides the prolonged neutralizing antibody production via …

H Hayashi, J Sun, Y Yanagida, T Otera, JA Tai… - Scientific Reports, 2023 - nature.com
Abstract Emerging SARS-CoV-2 Omicron variants are highly contagious with enhanced
immune escape mechanisms against the initially approved COVID-19 vaccines. Therefore …

Impact of timing and combination of different BNT162b2 and ChAdOx1-S COVID-19 basic and booster vaccinations on humoral immunogenicity and reactogenicity in …

S Dedroogh, S Schmiedl, PA Thürmann, K Graf… - Scientific Reports, 2023 - nature.com
In this single-center observational study with 1,206 participants, we prospectively evaluated
SARS-CoV-2-antibodies (anti-S RBD) and vaccine-related adverse drug reactions (ADR) …

[HTML][HTML] Vaccine effectiveness and duration of protection of COVID-19 mRNA vaccines against Delta and Omicron BA. 1 symptomatic and severe COVID-19 outcomes …

CRT Tchuem, V Auvigne, S Vaux, C Montagnat… - Vaccine, 2023 - Elsevier
The emergence of SARS-CoV-2 variants calls for continuous monitoring of vaccine
effectiveness (VE). We estimated the absolute effectiveness of complete 2-dose primary …