C–H deuteration has been intricately developed to satisfy the urgent need for site-selectively
deuterated organic frameworks. Deuteration has been primarily used to study kinetic isotope …

Biaryl scaffolds are found in natural products and drug molecules and exhibit a wide range
of biological activities. In past decade, the transition metal-catalyzed C–H arylation reaction …

Decarboxylative protonation is a general deletion tactic to replace polar carboxylic acid
groups with hydrogen or its isotope. Current methods rely on the pre‐activation of acids, non …

Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a
valuable tool for C–H activation and functionalization. Since the discovery of its unique …

Carboxylic acids are highly abundant in bioactive molecules. In this study, we describe the
late-stage β-C (sp3)–H deuteration of free carboxylic acids. On the basis of the finding that C …

Efficient and streamlined synthetic methods that facilitate the rapid build-up of structurally
diverse π-conjugated systems are of paramount importance in the quest for organic …

Catalytic asymmetric transformation is a powerful strategy for the introduction of chirality to
synthesize diverse nonracemic molecular entities. Chiral molecules play a significant role in …

Pd-catalysed C–H functionalisation of free carboxylic acids has drawn significant attention
over the last few years due to the predominance of carboxylic acid moieties in …

The direct acyl Sonogashira cross-coupling of carboxylic acids with terminal alkynes has
been achieved through Pd/Cu cooperative catalysis. In this reaction, the readily available …

As a widely existing functional group in organic molecules, the carboxyl group has
numerous advantageous characteristics such as great convenience for further …