Many clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-
associated protein 9 (Cas9)-based genome editing technologies take advantage of Cas …

Eukaryotic cells deploy overlapping repair pathways to resolve DNA damage.
Advancements in genome editing take advantage of these pathways to produce permanent …

The replisome quickly and accurately copies billions of DNA bases each cell division cycle.
However, it can make errors, especially when the template DNA is damaged. In these cases …

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of
eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was …

In the last two decades, an increasing amount of studies have investigated the use of
components based on carbon-(nano) materials in the engineering of neural interfaces, to …

PARP1 regulates the repair of DNA single-strand breaks generated directly, or during base
excision repair (BER). However, the role of PARP2 in these and other repair mechanisms is …

The replisome, the molecular machine dedicated to copying DNA, encounters a variety of
obstacles during S phase. Without a proper response to this replication stress, the genome …

RFWD3 is a recently identified Fanconi anemia protein FANCW whose E3 ligase activity
toward RPA is essential in homologous recombination (HR) repair. However, how RPA …

Fork reversal is a common response to replication stress, but it generates a DNA end that is
susceptible to degradation. Many fork protection factors block degradation, but how they …

BRCA1-deficient tumor cells have defects in homologous-recombination repair and
replication fork stability, resulting in PARP inhibitor sensitivity. Here, we demonstrate that a …