The molecular mechanisms of copper metabolism and its roles in human diseases

J Chen, Y Jiang, H Shi, Y Peng, X Fan, C Li - Pflügers Archiv-European …, 2020 - Springer
Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …

Advances in metal-induced oxidative stress and human disease

K Jomova, M Valko - Toxicology, 2011 - Elsevier
Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …

ATF3/SPI1/SLC31A1 signaling promotes cuproptosis induced by advanced glycosylation end products in diabetic myocardial injury

S Huo, Q Wang, W Shi, L Peng, Y Jiang, M Zhu… - International Journal of …, 2023 - mdpi.com
Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic
cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent …

Molecular mechanism of action of metformin: old or new insights?

G Rena, ER Pearson, K Sakamoto - Diabetologia, 2013 - Springer
Metformin is the first-line drug treatment for type 2 diabetes. Globally, over 100 million
patients are prescribed this drug annually. Metformin was discovered before the era of target …

The molecular mechanisms of defective copper metabolism in diabetic cardiomyopathy

X Cui, Y Wang, H Liu, M Shi, J Wang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention

S Brings, T Fleming, M Freichel… - International journal of …, 2017 - mdpi.com
Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid
adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is …

Aldazine-based colorimetric sensors for Cu2+ and Fe3+

N Narayanaswamy, T Govindaraju - Sensors and Actuators B: Chemical, 2012 - Elsevier
We have developed novel aldazine-based colorimetric chemosensors for Cu2+ and Fe3+.
The aldazine ligands were synthesized by simple condensation of 4-diethylamino …

An emerging role of defective copper metabolism in heart disease

Y Liu, J Miao - Nutrients, 2022 - mdpi.com
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …

Copper transporters and copper chaperones: roles in cardiovascular physiology and disease

T Fukai, M Ushio-Fukai… - American Journal of …, 2018 - journals.physiology.org
Copper (Cu) is an essential micronutrient but excess Cu is potentially toxic. Its important
propensity to cycle between two oxidation states accounts for its frequent presence as a …

Copper and diabetes: current research and prospect

W Chang, P Li - Molecular Nutrition & Food Research, 2023 - Wiley Online Library
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …