The molecular mechanisms of copper metabolism and its roles in human diseases
J Chen, Y Jiang, H Shi, Y Peng, X Fan, C Li - Pflügers Archiv-European …, 2020 - Springer
Copper is an essential element in cells; it can act as either a recipient or a donor of
electrons, participating in various reactions. However, an excess of copper ions in cells is …
electrons, participating in various reactions. However, an excess of copper ions in cells is …
Advances in metal-induced oxidative stress and human disease
Detailed studies in the past two decades have shown that redox active metals like iron (Fe),
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …
copper (Cu), chromium (Cr), cobalt (Co) and other metals undergo redox cycling reactions …
ATF3/SPI1/SLC31A1 signaling promotes cuproptosis induced by advanced glycosylation end products in diabetic myocardial injury
S Huo, Q Wang, W Shi, L Peng, Y Jiang, M Zhu… - International Journal of …, 2023 - mdpi.com
Cuproptosis resulting from copper (Cu) overload has not yet been investigated in diabetic
cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent …
cardiomyopathy (DCM). Advanced glycosylation end products (AGEs) induced by persistent …
Molecular mechanism of action of metformin: old or new insights?
G Rena, ER Pearson, K Sakamoto - Diabetologia, 2013 - Springer
Metformin is the first-line drug treatment for type 2 diabetes. Globally, over 100 million
patients are prescribed this drug annually. Metformin was discovered before the era of target …
patients are prescribed this drug annually. Metformin was discovered before the era of target …
The molecular mechanisms of defective copper metabolism in diabetic cardiomyopathy
X Cui, Y Wang, H Liu, M Shi, J Wang… - Oxidative Medicine and …, 2022 - Wiley Online Library
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …
pathology by regulating various important biological processes, including mitochondrial …
Dicarbonyls and advanced glycation end-products in the development of diabetic complications and targets for intervention
S Brings, T Fleming, M Freichel… - International journal of …, 2017 - mdpi.com
Advanced glycation end-products (AGEs) are non-enzymatic protein and amino acid
adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is …
adducts as well as DNA adducts which form from dicarbonyls and glucose. AGE formation is …
Aldazine-based colorimetric sensors for Cu2+ and Fe3+
N Narayanaswamy, T Govindaraju - Sensors and Actuators B: Chemical, 2012 - Elsevier
We have developed novel aldazine-based colorimetric chemosensors for Cu2+ and Fe3+.
The aldazine ligands were synthesized by simple condensation of 4-diethylamino …
The aldazine ligands were synthesized by simple condensation of 4-diethylamino …
An emerging role of defective copper metabolism in heart disease
Y Liu, J Miao - Nutrients, 2022 - mdpi.com
Copper is an essential trace metal element that significantly affects human physiology and
pathology by regulating various important biological processes, including mitochondrial …
pathology by regulating various important biological processes, including mitochondrial …
Copper transporters and copper chaperones: roles in cardiovascular physiology and disease
T Fukai, M Ushio-Fukai… - American Journal of …, 2018 - journals.physiology.org
Copper (Cu) is an essential micronutrient but excess Cu is potentially toxic. Its important
propensity to cycle between two oxidation states accounts for its frequent presence as a …
propensity to cycle between two oxidation states accounts for its frequent presence as a …
Copper and diabetes: current research and prospect
W Chang, P Li - Molecular Nutrition & Food Research, 2023 - Wiley Online Library
Copper is an essential trace metal for normal cellular functions; a lack of copper is reported
to impair the function of important copper‐binding enzymes, while excess copper could lead …
to impair the function of important copper‐binding enzymes, while excess copper could lead …