The clearance of surplus, broken, or dangerous components is key for maintaining cellular
homeostasis. The failure to remove protein aggregates, damaged organelles, or intracellular …

Ubiquitin-like proteins (Ubl's) are conjugated to target proteins or lipids to regulate their
activity, stability, subcellular localization, or macromolecular interactions. Similar to ubiquitin …

Nonalcoholic steatohepatitis (NASH) is a progressive disorder with aberrant lipid
accumulation and subsequent inflammatory and profibrotic response. Therapeutic efforts at …

The endoplasmic reticulum (ER) is the largest intracellular endomembrane system, enabling
protein and lipid synthesis, ion homeostasis, quality control of newly synthesized proteins …

Selective autophagy is a quality control pathway through which cellular components are
sequestered into double-membrane vesicles and delivered to specific intracellular …

Selective autophagy ensures recognition and removal of various cytosolic cargos. Hence,
aggregated proteins, damaged organelles, or pathogens are enclosed into the double …

Selective autophagy contributes to intracellular homeostasis by mediating the degradation
of cytoplasmic material such as aggregated proteins, damaged or over-abundant …

The selective removal of undesired or damaged mitochondria by autophagy, known as
mitophagy, is crucial for cellular homoeostasis, and prevents tumour diffusion …

The mitophagy receptor Nix interacts with LC3/GABARAP proteins, targeting mitochondria
into autophagosomes for degradation. Here we present evidence for phosphorylation-driven …

Autophagy plays a key role in cellular homeostasis, responding to various environmental
stresses. In particular, pathogen invasion leads to rapid induction of autophagy, which is …