Matrix-assisted laser desorption ionization–time of flight mass spectrometry: a fundamental shift in the routine practice of clinical microbiology

AE Clark, EJ Kaleta, A Arora… - Clinical microbiology …, 2013 - Am Soc Microbiol
Within the past decade, clinical microbiology laboratories experienced revolutionary
changes in the way in which microorganisms are identified, moving away from slow …

Advances in the development of new tuberculosis drugs and treatment regimens

A Zumla, P Nahid, ST Cole - Nature reviews Drug discovery, 2013 - nature.com
Despite the introduction 40 years ago of the inexpensive and effective four-drug (isoniazid,
rifampicin, pyrazinamide and ethambutol) treatment regimen, tuberculosis (TB) continues to …

Advances in tuberculosis diagnostics: the Xpert MTB/RIF assay and future prospects for a point-of-care test

SD Lawn, P Mwaba, M Bates, A Piatek… - The Lancet infectious …, 2013 - thelancet.com
Rapid progress has been made in the development of new diagnostic assays for
tuberculosis in recent years. New technologies have been developed and assessed, and …

[HTML][HTML] Functional signatures of human CD4 and CD8 T cell responses to Mycobacterium tuberculosis

T Prezzemolo, G Guggino, MP La Manna… - Frontiers in …, 2014 - frontiersin.org
With 1.4 million deaths and 8.7 million new cases in 2011, tuberculosis (TB) remains a
global health care problem and together with HIV and Malaria represents one of the three …

Prospects for tuberculosis elimination

C Dye, P Glaziou, K Floyd… - Annual review of public …, 2013 - annualreviews.org
The target for TB elimination is to reduce annual incidence to less than one case per million
population by 2050. Meeting that target requires a 1,000-fold reduction in incidence in little …

[HTML][HTML] Tuberculosis: epidemiology and control

G Sulis, A Roggi, A Matteelli… - Mediterranean journal of …, 2014 - ncbi.nlm.nih.gov
Tuberculosis (TB) is a major public health concern worldwide: despite a regular, although
slow, decline in incidence over the last decade, as many as 8.6 million new cases and 1.3 …

Scaling up interventions to achieve global tuberculosis control: progress and new developments

M Raviglione, B Marais, K Floyd, K Lönnroth… - The Lancet, 2012 - thelancet.com
Tuberculosis is still one of the most important causes of death worldwide. The 2010 Lancet
tuberculosis series provided a comprehensive overview of global control efforts and …

Evaluation of tuberculosis diagnostics in children: 1. Proposed clinical case definitions for classification of intrathoracic tuberculosis disease. Consensus from an …

SM Graham, T Ahmed, F Amanullah… - Journal of Infectious …, 2012 - academic.oup.com
There is a critical need for improved diagnosis of tuberculosis in children, particularly in
young children with intrathoracic disease as this represents the most common type of …

Role of apoptosis and autophagy in tuberculosis

A Lam, R Prabhu, CM Gross… - … of Physiology-Lung …, 2017 - journals.physiology.org
Tuberculosis (TB) is one of the oldest known human diseases and is transmitted by the
bacteria Mycobacterium tuberculosis (Mtb). TB has a rich history with evidence of TB …

[HTML][HTML] Rapid point of care diagnostic tests for viral and bacterial respiratory tract infections—needs, advances, and future prospects

A Zumla, JA Al-Tawfiq, VI Enne, M Kidd… - The Lancet Infectious …, 2014 - thelancet.com
Respiratory tract infections rank second as causes of adult and paediatric morbidity and
mortality worldwide. Respiratory tract infections are caused by many different bacteria …