Nanoparticle protein corona: from structure and function to therapeutic targeting

G Bashiri, MS Padilla, KL Swingle, SJ Shepherd… - Lab on a Chip, 2023 - pubs.rsc.org
Nanoparticle (NP)-based therapeutics have ushered in a new era in translational medicine.
However, despite the clinical success of NP technology, it is not well-understood how NPs …

Hard and soft protein corona of nanomaterials: Analysis and relevance

R García-Álvarez, M Vallet-Regí - Nanomaterials, 2021 - mdpi.com
Upon contact with a biological milieu, nanomaterials tend to interact with biomolecules
present in the media, especially proteins, leading to the formation of the so-called “protein …

In situ analysis of nanoparticle soft corona and dynamic evolution

D Baimanov, J Wang, J Zhang, K Liu, Y Cong… - Nature …, 2022 - nature.com
How soft corona, the protein corona's outer layer, contributes to biological identity of
nanomaterials is largely because capturing protein composition of the soft corona in situ …

Extracellular vesicles from human plasma and serum are carriers of extravesicular cargo—Implications for biomarker discovery

M Palviainen, M Saraswat, Z Varga, D Kitka… - PloS one, 2020 - journals.plos.org
Extracellular vesicles (EVs) in human blood are a potential source of biomarkers. To which
extent anticoagulation affects their concentration, cellular origin and protein composition is …

Mapping and identification of soft corona proteins at nanoparticles and their impact on cellular association

H Mohammad-Beigi, Y Hayashi, CM Zeuthen… - Nature …, 2020 - nature.com
The current understanding of the biological identity that nanoparticles may acquire in a
given biological milieu is mostly inferred from the hard component of the protein corona …

Protein corona and exosomes: new challenges and prospects

M Heidarzadeh, A Zarebkohan, R Rahbarghazi… - Cell Communication and …, 2023 - Springer
Recent advances in extracellular vesicle (EVs) detection and isolation methods have led to
the development of novel therapeutic modalities. Among different types of EVs, exosomes …

Mechanistic understanding of protein Corona formation around nanoparticles: old puzzles and new insights

K Nienhaus, GU Nienhaus - Small, 2023 - Wiley Online Library
Although a wide variety of nanoparticles (NPs) have been engineered for use as disease
markers or drug delivery agents, the number of nanomedicines in clinical use has hitherto …

In vivo protein corona on nanoparticles: does the control of all material parameters orient the biological behavior?

N Singh, C Marets, J Boudon, N Millot, L Saviot… - Nanoscale …, 2021 - pubs.rsc.org
Nanomaterials have a huge potential in research fields from nanomedicine to medical
devices. However, surface modifications of nanoparticles (NPs) and thus of their …

Engineering at the nano-bio interface: harnessing the protein corona towards nanoparticle design and function

RL Pinals, L Chio, F Ledesma, MP Landry - Analyst, 2020 - pubs.rsc.org
Unpredictable and uncontrollable protein adsorption on nanoparticles remains a
considerable challenge to achieving effective application of nanotechnologies within …

Spotlight on the protein corona of liposomes

N Onishchenko, D Tretiakova, E Vodovozova - Acta biomaterialia, 2021 - Elsevier
Although an established drug delivery platform, liposomes have not fulfilled their true
potential. In the body, interactions of liposomes are mediated by the layer of plasma proteins …