ATM, ATR, and DNA-PK: The Trinity at the Heart of the DNA Damage Response
AN Blackford, SP Jackson - Molecular cell, 2017 - cell.com
In vertebrate cells, the DNA damage response is controlled by three related kinases: ATM,
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
ATR, and DNA-PK. It has been 20 years since the cloning of ATR, the last of the three to be …
The essential kinase ATR: ensuring faithful duplication of a challenging genome
JC Saldivar, D Cortez, KA Cimprich - Nature reviews Molecular cell …, 2017 - nature.com
One way to preserve a rare book is to lock it away from all potential sources of damage. Of
course, an inaccessible book is also of little use, and the paper and ink will continue to …
course, an inaccessible book is also of little use, and the paper and ink will continue to …
Proteogenomics of non-smoking lung cancer in East Asia delineates molecular signatures of pathogenesis and progression
Summary Lung cancer in East Asia is characterized by a high percentage of never-smokers,
early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this …
early onset and predominant EGFR mutations. To illuminate the molecular phenotype of this …
DNA damage sensing by the ATM and ATR kinases
A Maréchal, L Zou - Cold Spring Harbor perspectives in …, 2013 - cshperspectives.cshlp.org
In eukaryotic cells, maintenance of genomic stability relies on the coordinated action of a
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
network of cellular processes, including DNA replication, DNA repair, cell-cycle progression …
ARID1A deficiency impairs the DNA damage checkpoint and sensitizes cells to PARP inhibitors
Abstract ARID1A, SWI/SNF chromatin remodeling complex subunit, is a recently identified
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
tumor suppressor that is mutated in a broad spectrum of human cancers. Thus, it is of …
ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A
CT Williamson, R Miller, HN Pemberton… - Nature …, 2016 - nature.com
Identifying genetic biomarkers of synthetic lethal drug sensitivity effects provides one
approach to the development of targeted cancer therapies. Mutations in ARID1A represent …
approach to the development of targeted cancer therapies. Mutations in ARID1A represent …
RPA-coated single-stranded DNA as a platform for post-translational modifications in the DNA damage response
A Maréchal, L Zou - Cell research, 2015 - nature.com
Abstract The Replication Protein A (RPA) complex is an essential regulator of eukaryotic
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …
DNA metabolism. RPA avidly binds to single-stranded DNA (ssDNA) through multiple …
Mechanisms of ATM activation
TT Paull - Annual review of biochemistry, 2015 - annualreviews.org
The ataxia-telangiectasia mutated (ATM) protein kinase is a master regulator of the DNA
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
damage response, and it coordinates checkpoint activation, DNA repair, and metabolic …
DNA mismatch repair and the DNA damage response
Z Li, AH Pearlman, P Hsieh - DNA repair, 2016 - Elsevier
This review discusses the role of DNA mismatch repair (MMR) in the DNA damage response
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
(DDR) that triggers cell cycle arrest and, in some cases, apoptosis. Although the focus is on …
The novel ATR inhibitor BAY 1895344 is efficacious as monotherapy and combined with DNA damage–inducing or repair–compromising therapies in preclinical …
AM Wengner, G Siemeister, U Lücking, J Lefranc… - Molecular cancer …, 2020 - AACR
The DNA damage response (DDR) secures the integrity of the genome of eukaryotic cells.
DDR deficiencies can promote tumorigenesis but concurrently may increase dependence …
DDR deficiencies can promote tumorigenesis but concurrently may increase dependence …