Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson's and Alzheimer's diseases: a …

R Cooray, V Gupta, C Suphioglu - Molecular neurobiology, 2020 - Springer
Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …

Intestinal barrier function and immune homeostasis are missing links in obesity and type 2 diabetes development

S Riedel, C Pheiffer, R Johnson, J Louw… - Frontiers in …, 2022 - frontiersin.org
Noncommunicable diseases, such as type 2 diabetes (T2D), place a burden on healthcare
systems worldwide. The rising prevalence of obesity, a major risk factor for T2D, is mainly …

The gut microbiome, endocannabinoids and metabolic disorders

FA Iannotti, V Di Marzo - Journal of Endocrinology, 2021 - joe.bioscientifica.com
Two complex systems are emerging as being deeply involved in the control of energy
metabolism. The intestinal microbiota, with its warehouse of genes, proteins and small …

[HTML][HTML] Intervention of five strains of Lactobacillus on obesity in mice induced by high-fat diet

M Wang, B Zhang, J Hu, S Nie, T Xiong… - Journal of Functional …, 2020 - Elsevier
The intervention effect of five Lactobacillus strains on the high-fat diet induced obese
C57BL/6J mice was investigated. C57BL/6J mice were randomly divided into normal diet …

What role does the endocannabinoid system play in the pathogenesis of obesity?

P Schulz, S Hryhorowicz, AM Rychter, A Zawada… - Nutrients, 2021 - mdpi.com
The endocannabinoid system (ECS) is an endogenous signaling system formed by specific
receptors (cannabinoid type 1 and type 2 (CB1 and CB2)), their endogenous ligands …

NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis

J Castel, G Li, O Onimus, E Leishman, PD Cani… - Molecular …, 2024 - nature.com
The N-acyl phosphatidylethanolamine-specific phospholipase D (NAPE-PLD) catalyzes the
production of N-acylethanolamines (NAEs), a family of endogenous bioactive lipids, which …

Genetic contributions to the etiology of anorexia nervosa: New perspectives in molecular diagnosis and treatment

S Paolacci, AK Kiani, E Manara… - Molecular genetics & …, 2020 - Wiley Online Library
Background Anorexia nervosa is a multifactorial eating disorder that manifests with self‐
starvation, extreme anxiety, hyperactivity, and amenorrhea. Long‐term effects include organ …

FAAH rs324420 Polymorphism: Biological Pathways, Impact on Elite Athletic Performance and Insights for Sport Medicine

HH Silva, V Tavares, BV Neto, F Cerqueira, R Medeiros… - Genes, 2023 - mdpi.com
Gene variation linked to physiological functions is recognised to affect elite athletic
performance by modulating training and competition-enabling behaviour. The fatty acid …

The endocannabinoid system in pediatric inflammatory and immune diseases

M Argenziano, C Tortora, G Bellini, A Di Paola… - International journal of …, 2019 - mdpi.com
Endocannabinoid system consists of cannabinoid type 1 (CB1) and cannabinoid type 2
(CB2) receptors, their endogenous ligands, and the enzymes responsible for their synthesis …

Association between the FAAH C385A variant (rs324420) and obesity-related traits: a systematic review

OD Lopez-Cortes, F Trujillo-Sanchez… - International Journal of …, 2024 - nature.com
Background Overweight and obesity are the consequence of a sustained positive energy
balance. Twin studies show high heritability rates pointing to genetics as one of the principal …