Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most
clinical settings. Cancer is a systemic disease that induces many functional and …

Abstract Coronavirus disease 2019 (COVID-19) and its causative virus, SARS-CoV-2, pose
considerable challenges for the management of oncology patients. COVID-19 presents as a …

Patients with cancer are presumed to be at increased risk of severe COVID-19 outcomes
due to underlying malignancy and treatment-induced immunosuppression. Of the first 178 …

Quantitative lymphocyte alterations are frequent in patients with cancer, and strongly impact
prognosis and survival. The development of cancers in immunosuppressed patients has …

Depending on the initiating stimulus, cancer cell death can be immunogenic or
nonimmunogenic. Immunogenic cell death (ICD) involves changes in the composition of the …

Antineoplastic chemotherapies are particularly efficient when they elicit immunogenic cell
death, thus provoking an anticancer immune response. Here we demonstrate that …

Objective: Our aim was to determine the prognostic significance of the systemic-immune-
inflammation index (SIII) in patients with resectable pancreatic cancer, using cancer-specific …

Glutamine is a major dietary amino acid that is both a fuel and nitrogen donor for healing
tissues damaged by chemotherapy and radiation. Evidence supports the benefit of oral …

The outcome of chemotherapy can be influenced by the host immune system at multiple
levels. Chemotherapy can kill cancer cells by causing them to elicit an immune response or …

Viral infections can give rise to a systemic decrease in the total number of lymphocytes in the
blood, referred to as lymphopenia. Lymphopenia may affect the host adaptive immune …