Chitinases belong to the evolutionarily conserved glycosyl hydrolase family 18 (GH18). They
catalyze degradation of chitin to N-acetylglucosamine by hydrolysis of the β-(1-4)-glycosidic …

Irritable bowel syndrome with diarrhea (IBS-D) is chronic intestinal dysfunction with diarrhea
and other complicated clinical symptoms, and it has a great impact on the daily life and …

Visceral pain (VP) is a global problem with complex etiologies and limited therapeutic
options. Guanylyl cyclase C (GUCY2C), an intestinal receptor producing cyclic GMP (cGMP) …

Background Dysregulation of gut microbiota–host bile acid (BA) co-metabolism is a critical
pathogenic factor of diarrhea-predominant irritable bowel syndrome (IBS-D). Traditional …

Introduction: Irritable bowel syndrome (IBS) is a complex functional gut disorder that typically
manifests in early adult years. More than a third of IBS patients are diagnosed with …

The human nociceptor-specific voltage-gated sodium channel 1.7 (hNaV1. 7) is critical for
sensing various types of somatic pain, but it appears not to play a primary role in acute …

Background Persistent visceral hypersensitivity is a key component of functional and
inflammatory gastrointestinal diseases. Current animal models fail to fully reproduce the …

Background Irritable bowel syndrome (IBS) is a chronic gastrointestinal disorder for which
no diagnostic tools are currently available. Patients are diagnosed using the Rome IV …

Objective Adults with irritable bowel syndrome (IBS) often report extraintestinal pain, fatigue,
and sleep disturbances in addition to abdominal pain. Few interventions have sought to …

With a global estimated prevalence of 15%, 74 irritable bowel syndrome (IBS) is both the
most common visceral pain disorder and gastrointestinal disorder. 34 Symptoms include …