Normal circulatory function is a key determinant of disease-free life expectancy (healthspan).
Indeed, pathologies affecting the cardiovascular system, which are growing in prevalence …

Heart failure with preserved ejection fraction (HFpEF) represents one of the greatest
challenges facing cardiovascular medicine today. Despite being the most common form of …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

Post-translational modifications (PTMs) have been proposed as a link between the oxidative
stress-inflammation-ageing trinity, thereby affecting several hallmarks of ageing …

Background: High salt intake is the leading dietary risk factor for cardiovascular diseases.
Although clinical evidence suggests that high salt intake is associated with nonalcoholic fatty …

The heterocellular nature of the heart has been receiving increasing attention in recent
years. In addition to cardiomyocytes as the prototypical cell type of the heart, non-myocytes …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Cardiovascular diseases and specifically heart failure (HF) impact global health and impose
a significant economic burden on society. Despite current advances in standard of care, the …

Heart failure with preserved ejection fraction (HFpEF) poses therapeutic challenges due to
the limited treatment options. Building upon our previous research that demonstrates the …

BACKGROUND: Progressive cardiac fibrosis leads to ventricular wall stiffness, cardiac
dysfunction, and eventually heart failure, but the underlying mechanism remains …