The fitness costs of antibiotic resistance mutations
Antibiotic resistance is increasing in pathogenic microbial populations and is thus a major
threat to public health. The fate of a resistance mutation in pathogen populations is …
threat to public health. The fate of a resistance mutation in pathogen populations is …
Predicting evolution
M Lässig, V Mustonen, AM Walczak - Nature ecology & evolution, 2017 - nature.com
The face of evolutionary biology is changing: from reconstructing and analysing the past to
predicting future evolutionary processes. Recent developments include prediction of …
predicting future evolutionary processes. Recent developments include prediction of …
Evolutionary mechanisms shaping the maintenance of antibiotic resistance
Antibiotics target essential cellular functions but bacteria can become resistant by acquiring
either exogenous resistance genes or chromosomal mutations. Resistance mutations …
either exogenous resistance genes or chromosomal mutations. Resistance mutations …
Experimental design, population dynamics, and diversity in microbial experimental evolution
In experimental evolution, laboratory-controlled conditions select for the adaptation of
species, which can be monitored in real time. Despite the current popularity of such …
species, which can be monitored in real time. Despite the current popularity of such …
Microbial experimental evolution–a proving ground for evolutionary theory and a tool for discovery
MJ McDonald - EMBO reports, 2019 - embopress.org
Microbial experimental evolution uses controlled laboratory populations to study the
mechanisms of evolution. The molecular analysis of evolved populations enables empirical …
mechanisms of evolution. The molecular analysis of evolved populations enables empirical …
Putative Compensatory Mutations in the rpoC Gene of Rifampin-Resistant Mycobacterium tuberculosis Are Associated with Ongoing Transmission
M De Vos, B Müller, S Borrell, PA Black… - Antimicrobial agents …, 2013 - Am Soc Microbiol
Rifampin resistance in clinical isolates of Mycobacterium tuberculosis arises primarily
through the selection of bacterial variants harboring mutations in the 81-bp rifampin …
through the selection of bacterial variants harboring mutations in the 81-bp rifampin …
The utility of Fisher's geometric model in evolutionary genetics
O Tenaillon - Annual review of ecology, evolution, and …, 2014 - annualreviews.org
The accumulation of data on the genomic bases of adaptation has triggered renewed
interest in theoretical models of adaptation. Among these models, Fisher's geometric model …
interest in theoretical models of adaptation. Among these models, Fisher's geometric model …
Inference of distribution of fitness effects and proportion of adaptive substitutions from polymorphism data
The distribution of fitness effects (DFE) encompasses the fraction of deleterious, neutral, and
beneficial mutations. It conditions the evolutionary trajectory of populations, as well as the …
beneficial mutations. It conditions the evolutionary trajectory of populations, as well as the …
Adaptive resistance to antibiotics in bacteria: a systems biology perspective
S Sandoval‐Motta, M Aldana - Wiley Interdisciplinary Reviews …, 2016 - Wiley Online Library
Despite all the major breakthroughs in antibiotic development and treatment procedures,
there is still no long‐term solution to the bacterial antibiotic resistance problem. Among all …
there is still no long‐term solution to the bacterial antibiotic resistance problem. Among all …
Multidrug resistance (MDR) and collateral sensitivity in bacteria, with special attention to genetic and evolutionary aspects and to the perspectives of antimicrobial …
Antibiotic poly-resistance (multidrug-, extreme-, and pan-drug resistance) is controlled by
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …
adaptive evolution. Darwinian and Lamarckian interpretations of resistance evolution are …