Apoptosis is the programmed cell death which maintains the healthy survival/death balance
in metazoan cells. Defect in apoptosis can cause cancer or autoimmunity, while enhanced …

Survivin, a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases
and blocks cell death, is highly expressed in most cancers and is associated with a poor …

The improper distribution of chromosomes during mitosis compromises cellular functions
and can reduce cellular fitness or contribute to malignant transformation. As a …

Platinum-based drugs, and in particular cis-diamminedichloroplatinum (II)(best known as
cisplatin), are employed for the treatment of a wide array of solid malignancies, including …

Abstract Extracellular vesicles (EVs) are 30–150 nm membrane-bound vesicles naturally
secreted by cells and play important roles in intercellular communication by delivering …

As a pleiotropic cytokine, interleukin-6 (IL-6) not only regulates the cellular immune
response, but it also promotes tumor development by activating multiple carcinogenic …

Data on gastroenteropancreatic neuroendocrine neoplasms (NEN) G3 (well-differentiated
neuroendocrine tumors (NET G3) and neuroendocrine carcinoma (NEC)) are limited. We …

Apoptosis is a tightly regulated cell suicide program that plays an essential role in the
development and maintenance of tissue homeostasis by eliminating unnecessary or harmful …

Due to the interesting magnetic and electrical properties with good chemical and thermal
stabilities, nickel ferrite nanoparticles are being utilized in many applications including …

Abstract PD-1/PD-L1 blockade therapy that eliminates T-cell inhibition signals is successful,
but poor benefits are often observed. Increasing T-cell infiltration and quantity of PD-1/PD-L1 …