The pathological processes leading to synapse loss, neuronal loss, brain atrophy and
gliosis in Alzheimer's disease (AD) and their relation to vascular disease and immunological …

Abstract Brain arteriolosclerosis (B-ASC), characterized by pathologic arteriolar wall
thickening, is a common finding at autopsy in aged persons and is associated with cognitive …

Cerebral endothelial cells and their linking tight junctions form a unique, dynamic and multi-
functional interface, the blood-brain barrier (BBB). The endothelium is regulated by …

Increasing evidence suggests that inflammatory responses are involved in the progression
of brain injuries induced by a diverse range of insults, including ischemia, hemorrhage …

Prevalence of dementia continues to increase because of the aging population and limited
treatment options. Cerebral small vessel disease and Alzheimer disease are the two most …

Alzheimer's disease (AD) and cerebral small vessel disease (cSVD) are the two main
causes of dementia with blood–brain barrier (BBB) breakdown being a common contributor …

Alzheimer's disease (AD) is the most common neurodegenerative disease, affecting millions
of people worldwide. The classical hallmarks of AD include extracellular beta-amyloid (Aβ) …

Blood-brain barrier (BBB) leakage is considered an important underlying process in both
cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this …

Diabetes contributes to the onset of various diseases, including cancer and cardiovascular
and neurodegenerative diseases. Recent studies have highlighted the similarities and …

Normal aging is characterized by declines in processing speed, learning, memory, and
executive function even in the absence of neurodegenerative diseases such as Alzheimer's …