Cancer heterogeneity constitutes the major source of disease progression and therapy
failure. Tumors comprise functionally diverse subpopulations, with cancer stem cells (CSCs) …

Cancer stem cells (CSC) are associated with the mechanisms of chemoresistance to
different cytotoxic drugs or radiotherapy, as well as with tumor relapse and a poor prognosis …

Epigenetic and metabolic alterations incancer cells are highly associated. Glioblastoma
multiforme (GBM) is a complicated pathological process with dysregulated methylation and …

Introduction The importance of fatty acid oxidation (FAO) in the bioenergetics of glioblastoma
(GBM) is being realized. Etomoxir (ETO), a carnitine palmitoyltransferase 1 (CPT1) inhibitor …

Background Glioblastoma (GBM), one of the most lethal tumors, exhibits a highly infiltrative
phenotype. Here, we identified transcription factors (TFs) that collectively modulate invasion …

ONC201 is the first member of the imipridone family of anticancer drugs to enter the clinic for
the treatment of diverse solid and hematologic cancers. A subset of pediatric and adult …

Mitochondrial complex I (CI) as a critical multifunctional respiratory complex of electron
transport chain (ETC) in mitochondrial oxidative phosphorylation has been identified as vital …

Head and neck cancer is a major health problem worldwide, with most cases arising in the
oral cavity. Oral squamous cell carcinoma (OSCC) is the most common type of oral cancer …

Glioblastoma stem cells (GSCs) are cells with a self-renewal ability and capacity to initiate
tumors upon serial transplantation that have been linked to tumor cell heterogeneity. Most …

Background Rheumatoid arthritis (RA) is a common chronic and systemic autoimmune
disease characterized by persistent inflammation and hyperplasia of the synovial …