Nonsteroidal anti‐inflammatory drugs (NSAIDs) inhibit the enzyme cyclooxygenase (COX),
which forms prostaglandins involved in pain and inflammation. COX inhibitors have …

Paracetamol (acetaminophen) is the most commonly used drug in the world, with a long
record of use in acute and chronic pain. In recent years, the benefits of paracetamol use in …

Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) of the phenylacetic acid class
with anti-inflammatory, analgesic, and antipyretic properties. Contrary to the action of many …

Nonsteroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen have a long history of safe
and effective use as both prescription and over-the-counter (OTC) analgesics/antipyretics …

The composition of the gut microbiome with the use of non-steroidal anti-inflammatory drugs
(NSAIDs) has not been fully characterized. Drug use within the past 30 days was …

OBJECTIVE: To update evidence for available therapies in the treatment of hip and knee
osteoarthritis (OA) and to examine whether research evidence has changed from 31 …

Ibuprofen first came to market about 50 years ago and rapidly moved to over-the-counter
(OTC) sales. In April 2019, the National Agency for the Safety of Medicines and Health …

PURPOSE: To develop concise, patient-focussed, up to date, evidence-based, expert
consensus recommendations for the management of hip and knee osteoarthritis (OA), which …

Pain is a complex phenomenon caused by noxious sensory stimuli or neuropathological
mechanisms. An individual's memories, expectations, and emotions modify the experience …

PURPOSE: As a prelude to developing updated, evidence-based, international consensus
recommendations for the management of hip and knee osteoarthritis (OA), the Osteoarthritis …