Background Substance use disorder (SUD) remains a significant public health issue. A
greater understanding of how genes and environment interact to regulate phenotypes …

After more than 10 years of accumulated efforts, genome-wide association studies (GWAS)
have led to many findings, most of which have been deposited into the GWAS Catalog …

Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of
stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we …

Abstract Purpose of Review With the advent of the genome-wide association study (GWAS),
our understanding of the genetics of addiction has made significant strides forward. Here …

Back pain (BP) is a common condition of major social importance and poorly understood
pathogenesis. Combining data from the UK Biobank and CHARGE consortium cohorts …

Genome-wide association studies (GWAS) have identified more than 100 loci that show
robust association with schizophrenia risk. However, due to the complexity of linkage …

As our understanding of genetics has improved, genome-wide association studies (GWAS)
have identified numerous variants associated with lifestyle behaviours and health outcomes …

Background Addictive disorders are a class of chronic, relapsing mental disorders that are
responsible for increased risk of mental and medical disorders and represent the largest …

Cigarette smoking is a leading modifiable cause of death worldwide. We hypothesized that
cigarette smoking induces extensive transcriptomic changes that lead to target-organ …

Cigarette smoking is a leading cause of preventable mortality worldwide. Nicotine
dependence, which reduces the likelihood of quitting smoking, is a heritable trait with firmly …