The perception that intracellular lipolysis is a straightforward process that releases fatty
acids from fat stores in adipose tissue to generate energy has experienced major revisions …

Background Non-alcoholic fatty liver disease, or as recently proposed 'metabolic-associated
fatty liver disease'(MAFLD), is characterized by pathological accumulation of triglycerides …

Tumor cellular metabolism exhibits distinguishing features that collectively enhance
biomass synthesis while maintaining redox balance and cellular homeostasis. These …

Agricultural and household applications of pyrethroid insecticides have significantly
increased residual concentrations in living cells and environments. The enhanced …

Mammalian carboxylesterases (CEs) are key enzymes from the serine hydrolase
superfamily. In the human body, two predominant carboxylesterases (CES1 and CES2) …

The liver performs numerous vital functions, including the detoxification of blood before
access to the brain while simultaneously secreting and internalizing scores of proteins and …

Enzymes and their regulations are employed as indicators for various diseases, including
cancer. To directly analyze the activity of the enzymes within a biological system, enzyme …

Mild‐temperature photothermal therapy (PTT) of tumors has been intensively explored and
adopted in preclinical/clinical trials in recent years. Nevertheless, tumor thermoresistance …

Carboxylesterase (CE) is crucial in metabolizing ester-containing biomolecules and is
particularly significant in liver metabolic diseases. Herein, we present the first activatable …

Carboxylesterase (CES) 1 is the most abundant drug-metabolizing enzyme in human livers,
comprising approximately 1% of the entire liver proteome. CES1 is responsible for 80 …