Pursuit of a perfect insulin
Insulin remains indispensable in the treatment of diabetes, but its use is hampered by its
narrow therapeutic index. Although advances in peptide chemistry and recombinant DNA …
narrow therapeutic index. Although advances in peptide chemistry and recombinant DNA …
[HTML][HTML] 'Smart'insulin-delivery technologies and intrinsic glucose-responsive insulin analogues
Insulin replacement therapy for diabetes mellitus seeks to minimise excursions in blood
glucose concentration above or below the therapeutic range (hyper-or hypoglycaemia). To …
glucose concentration above or below the therapeutic range (hyper-or hypoglycaemia). To …
Synergistic activation of the insulin receptor via two distinct sites
Insulin receptor (IR) signaling controls multiple facets of animal physiology. Maximally four
insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise …
insulins bind to IR at two distinct sites, termed site-1 and site-2. However, the precise …
Glucose-responsive insulin by molecular and physical design
The concept of a glucose-responsive insulin (GRI) has been a recent objective of diabetes
technology. The idea behind the GRI is to create a therapeutic that modulates its potency …
technology. The idea behind the GRI is to create a therapeutic that modulates its potency …
The chemical synthesis of insulin: an enduring challenge
The pancreatic peptide hormone insulin, first discovered exactly 100 years ago, is essential
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …
for glycemic control and is used as a therapeutic for the treatment of type 1 and, increasingly …
Viral insulin-like peptides activate human insulin and IGF-1 receptor signaling: A paradigm shift for host–microbe interactions
E Altindis, W Cai, M Sakaguchi… - Proceedings of the …, 2018 - National Acad Sciences
Viruses are the most abundant biological entities and carry a wide variety of genetic
material, including the ability to encode host-like proteins. Here we show that viruses carry …
material, including the ability to encode host-like proteins. Here we show that viruses carry …
Insertion of a synthetic switch into insulin provides metabolite-dependent regulation of hormone–receptor activation
YS Chen, J Gleaton, Y Yang… - Proceedings of the …, 2021 - National Acad Sciences
Insulin-signaling requires conformational change: whereas the free hormone and its
receptor each adopt autoinhibited conformations, their binding leads to structural …
receptor each adopt autoinhibited conformations, their binding leads to structural …
Substitution of an internal disulfide bridge with a diselenide enhances both foldability and stability of human insulin
O Weil‐Ktorza, N Rege, S Lansky… - … A European Journal, 2019 - Wiley Online Library
Insulin analogues, mainstays in the modern treatment of diabetes mellitus, exemplify the
utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the …
utility of protein engineering in molecular pharmacology. Whereas chemical syntheses of the …
The ABC of insulin: the organic chemistry of a small protein
M Østergaard, NK Mishra… - Chemistry–A European …, 2020 - Wiley Online Library
Insulin is a small protein crucial for regulating the blood glucose level in all animals. Since
1922 it has been used for the treatment of patients with diabetes. Despite consisting of just …
1922 it has been used for the treatment of patients with diabetes. Despite consisting of just …
Insulin—from its discovery to the industrial synthesis of modern insulin analogues
L Moroder, HJ Musiol - Angewandte Chemie International …, 2017 - Wiley Online Library
After the discovery of insulin as a drug for diabetes, the pharmaceutical companies were
faced with the challenge to meet the demand for insulin with the highest possible degree of …
faced with the challenge to meet the demand for insulin with the highest possible degree of …