Resistance arteries and downstream arterioles in the peripheral microcirculation contribute
substantially to peripheral vascular resistance, control of blood pressure, the distribution of …

Myogenic tone is a hall-mark feature of arterioles in the microcirculation. This pressure-
induced, contractile activation of vascular smooth muscle cells (VSMCs) in the wall of these …

Progesterone acts directly on vascular smooth muscle cells (VSMCs) through activation of
membrane progesterone receptor α (mPRα)-dependent signaling to rapidly decrease …

Acute myocardial infarction (AMI) is a condition with high morbidity and mortality, for which
effective treatments are lacking. Allicin has been reported to exert therapeutic effects on AMI …

Voltage-gated Kv7 (or KCNQ) channels control activity of excitable cells, including vascular
smooth muscle cells (VSMCs), by setting their resting membrane potential and controlling …

Rho family GTPases are molecular switches best known for their pivotal role in dynamic
regulation of the actin cytoskeleton, but also of cellular morphology, motility, adhesion and …

Renal autoregulation is critical in maintaining stable renal blood flow (RBF) and glomerular
filtration rate (GFR). Renal ischemia-reperfusion (IR)-induced kidney injury is characterized …

In ANG II-dependent hypertension, ANG II activates ANG II type 1 receptors (AT1Rs),
elevating blood pressure and increasing renal afferent arteriolar resistance (AAR). The …

Aminoglycoside nephrotoxicity stands as a primary contributor to the development of acute
intrinsic renal failure. Distinctive characteristic associated with this nephrotoxicity is the …

Purinergic P2X1, P2X7 and angiotensin AT1 receptors interactions in the regulation of renal
afferent arteriole in angiotensin II Page 1 1 Purinergic P2X1, P2X7 and angiotensin AT1 …