Doxorubicin (DOX) is a powerful and commonly used chemotherapeutic drug, used alone or
in combination in a variety of cancers, while it has been found to cause serious cardiac side …

Doxorubicin (DOX) is one of the most effective anticancer drugs to treat various forms of
cancers; however, its therapeutic utility is severely limited by its associated cardiotoxicity …

Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal
physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases …

A number of controlled trials have previously found that in some contexts, vitamin C can
have beneficial effects on blood pressure, infections, bronchoconstriction, atrial fibrillation …

Dexrazoxane (DXZ) reduces cytotoxicity caused by Doxorubicin (DOX). However, the
mechanism of DXZ in ferroptosis and cardiomyopathy remains unclear. This research …

Prolonged elevated oxidative stress (OS) possesses negative effect on cell structure and
functioning, and is associated with the development of numerous disorders. Naturally …

Doxorubicin (DOX) is a chemotherapeutic agent with marked, dose-dependent cardiotoxicity
that leads to tachycardia, atrial and ventricular arrhythmia, and irreversible heart failure …

Background: Doxorubicin (Dox) can induce endotheliotoxicity and damage the vascular
endothelium (VE). The most principle mechanism might be excess reactive oxygen species …

Doxorubicin (DOX), is a very effective chemotherapeutic agent against cancer whose clinical
use is limited by toxicity. Different strategies have been proposed to attenuate toxicity …

Chemotherapy with anthracycline-based regimens remains a cornerstone of treatment of
many solid and blood tumors but is associated with a significant risk of cardiotoxicity, which …