[HTML][HTML] Proactive and reactive roles of TGF-β in EMT-induced plasticity

NA Kuburich, T Sabapathy, BR Demestichas… - Seminars in cancer …, 2023 - Elsevier
Cancer cells adapt to varying stress conditions to survive through plasticity. Stem cells
exhibit a high degree of plasticity, allowing them to generate more stem cells or differentiate …

Autophagy and breast cancer: connected in growth, progression, and therapy

Q Wu, D Sharma - Cells, 2023 - mdpi.com
Despite an increase in the incidence of breast cancer worldwide, overall prognosis has
been consistently improving owing to the development of multiple targeted therapies and …

A synthetic metastatic niche reveals antitumor neutrophils drive breast cancer metastatic dormancy in the lungs

J Wang, R Ocadiz-Ruiz, MS Hall, GG Bushnell… - Nature …, 2023 - nature.com
Biomaterial scaffolds mimicking the environment in metastatic organs can deconstruct
complex signals and facilitate the study of cancer progression and metastasis. Here we …

Dormancy in breast cancer

E Dalla, A Sreekumar… - Cold Spring …, 2023 - perspectivesinmedicine.cshlp.org
The pattern of delayed recurrence in a subset of breast cancer patients has long been
explained by a model that incorporates a variable period of cellular or tumor mass dormancy …

Oncobiology and treatment of breast cancer in young women

R Kumar, C Abreu, M Toi, S Saini, S Casimiro… - Cancer and Metastasis …, 2022 - Springer
Female breast cancer emerged as the leading cancer type in terms of incidence globally in
2020. Although mortality due to breast cancer has improved during the past three decades …

GRHL2 motif is associated with intratumor heterogeneity of cis-regulatory elements in luminal breast cancer

K Kumegawa, Y Takahashi, S Saeki, L Yang… - NPJ Breast …, 2022 - nature.com
In breast cancer patients, tumor heterogeneity is associated with prognosis and therapeutic
response; however, the epigenetic diversity that exists in primary tumors remains unknown …

[HTML][HTML] Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3

TN Trotter, CE Dagotto, D Serra, T Wang, X Yang… - JCI insight, 2023 - ncbi.nlm.nih.gov
Approximately 30% of breast cancer survivors deemed free of disease will experience
locoregional or metastatic recurrence even up to 30 years after initial diagnosis, yet how …

Extracellular vesicles in breast cancer: from biology and function to clinical diagnosis and therapeutic management

S Loric, JA Denis, C Desbene, M Sabbah… - International journal of …, 2023 - mdpi.com
Breast cancer (BC) is the first worldwide most frequent cancer in both sexes and the most
commonly diagnosed in females. Although BC mortality has been thoroughly declining over …

Vessel co-option and angiotropic extravascular migratory metastasis: a continuum of tumour growth and spread?

C Lugassy, PB Vermeulen, D Ribatti, F Pezzella… - British Journal of …, 2022 - nature.com
Two fields of cancer research have emerged dealing with the biology of tumour cells
localised to the abluminal vascular surface: vessel co-option (VCo), a non-angiogenic mode …

Onco-Breastomics: An Eco-Evo-Devo Holistic Approach

AN Neagu, D Whitham, P Bruno, A Arshad… - International Journal of …, 2024 - mdpi.com
Known as a diverse collection of neoplastic diseases, breast cancer (BC) can be
hyperbolically characterized as a dynamic pseudo-organ, a living organism able to build a …