Abstract HDAC6, a class IIB HDAC isoenzyme, stands unique in its structural and
physiological functions. Besides histone modification, largely due to its cytoplasmic …

Epigenetic aberrations, which are recognized as key drivers of several human diseases, are
often caused by genetic defects that result in functional deregulation of epigenetic proteins …

To date, there is rapidly increasing evidence for host–microbe interaction at virtually all
levels of complexity, ranging from direct cell‐to‐cell communication to extensive systemic …

Hydroxamate‐based histone deacetylase inhibitors (HDACIs) have been approved as
therapeutic agents by the US Food and Drug Administration for use in oncology …

Background HDAC6, a structurally and functionally distinct member of the HDAC family, is
an integral part of multiple cellular functions such as cell proliferation, apoptosis …

Histone deacetylase (HDAC) 6 is a member of the class IIb HDAC family. This enzyme is
zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with …

Central nervous system (CNS) neurodegenerative diseases are characterized by faulty
intracellular transport, cognition, and aggregate regulation. Traditionally, neuroprotection …

Immune-mediated diseases are clinically heterogeneous but they share genetic and
pathogenic mechanisms. These diseases may develop from the interplay of genetic factors …

Modulation of gene expression is a constant and necessary event for mammalian brain
function. An important way of regulating gene expression is through the remodeling of …

The development of physical dependence and addiction disorders due to misuse of opioid
analgesics is a major concern with pain therapeutics. We developed a mouse model of …