The past decade has seen the emergence of endoplasmic reticulum (ER) chaperones as
key determinants of contact formation between mitochondria and the ER on the …

Introduction: Despite the availability of new vaccines for SARS-CoV-2, there has been slow
uptake and problems with supply in some parts of the world. Hence, there is still a necessity …

Cancer is a primary global health concern, and researchers seek innovative approaches to
combat the disease. Clinical bioinformatics and high-throughput proteomics technologies …

Certain selective serotonin reuptake inhibitors (SSRIs) have anti-inflammatory effects in
preclinical models, and recent clinical studies suggest that fluvoxamine can prevent …

Abstract The sigma-1 and sigma-2 receptors were first discovered in the 1960s and were
thought to be a form of opioid receptors initially. Over time, more was gradually learned …

The greater prevalence and incidence of Parkinson's disease (PD) in men suggest a
beneficial effect of sex hormones. Neuroactive steroids have neuroprotective activities thus …

These unprecedented times have forced the scientific community to gather to face the
COVID-19 pandemic. Efforts in diverse directions have been made. A multi-university team …

Though a great many of studies on the development of antidepressants for the therapy of
major depression disorder (MDD) and the development of antidepressants have been …

Sigma-1 receptor (σ1R) ligands have been shown to be effective at relieving neuropathic
and inflammatory pain, but have not yet been tested in experimental models of fibromyalgia …

Abstract The Sigma-1 receptor (σ1R) is highly expressed in the primary sensory neurons
(PSNs) that are the critical site of initiation and maintenance of pain following peripheral …