Native mass spectrometry (MS) involves the analysis and characterization of
macromolecules, predominantly intact proteins and protein complexes, whereby as much as …

Small molecule drug discovery has been propelled by the continual development of novel
scientific methodologies to occasion therapeutic advances. Although established …

Native mass spectrometry (nMS) is evolving into a workhorse for structural biology. The
plethora of online and offline preparation, separation, and purification methods as well as …

The proteome, or collection of proteoforms expressed in a biological system, is dynamic and
heterogeneous. As our appreciation for the complexity of the proteome has evolved, so have …

We describe a set of simple devices for surface-induced dissociation of proteins and protein
complexes on three instrument platforms. All of the devices use a novel yet simple split lens …

Here, we describe a digital-waveform dual-quadrupole mass spectrometer that enhances
the performance of our drift tube FT-IMS high-resolution Orbitrap mass spectrometer (MS) …

Native mass spectrometry (nMS) is a rapidly growing method for the characterization of large
proteins and protein complexes, preserving “native” non‐covalent inter‐and intramolecular …

We describe the implementation of a simple three-electrode surface-induced dissociation
(SID) cell on a cyclic ion mobility spectrometer (cIMS) and demonstrate the utility of …

Native mass spectrometry (nMS), particularly in conjunction with gas-phase ion mobility
spectrometry measurements, has proven useful as a structural biology tool for evaluating the …

Charge transfer dissociation mass spectrometry (CTD-MS) has been shown to induce high
energy fragmentation of biological ions in the gas phase and provide fragmentation spectra …