Bacteria can rapidly and reversibly respond to changing environments via complex
transcriptional and post-transcriptional regulatory mechanisms. Many of these adaptations …

The presence of an abnormal amount of single-stranded DNA in the bacterial cell constitutes
a genotoxic alarm signal that induces the SOS response, a broad regulatory network found …

Under conditions of nutrient deprivation or stress, or as cells enter stationary phase,
Escherichia coli and related bacteria increase the accumulation of RpoS, a specialized …

During stress, bacteria undergo extensive physiological transformations, many of which are
coordinated by ppGpp. Although ppGpp is best known for enhancing cellular resilience by …

Conditions that sustain constant bacterial growth are seldom found in nature. Oligotrophic
environments and competition among microorganisms force bacteria to be able to adapt …

Recent advances in the area of bacterial DNA damage responses are reviewed here. The
SOS pathway is still the major paradigm of bacterial DNA damage response, and recent …

Members of the AAA+ protein superfamily contribute to many diverse aspects of protein
homeostasis in prokaryotic cells. As a fundamental component of numerous proteolytic …

One promise of synthetic biology is the creation of genetic circuitry that enables the
execution of logical programming in living cells. Such 'wet programming'is positioned to …

The carbon storage regulator (Csr) or repressor of stationary phase metabolites (Rsm)
system of Gammaproteobacteria is among the most complex and best-studied …

Inappropriate and injudicious use of antimicrobial drugs in human health, hygiene,
agriculture, animal husbandry and food industries has contributed significantly to rapid …