Reactive oxygen species (ROS) generated by NADPH oxidase play an important role in
antimicrobial host defense and inflammation. Their deficiency in humans results in recurrent …

Reactive oxygen species (ROS) are deadly weapons used by phagocytes and other cell
types, such as lung epithelial cells, against pathogens. ROS can kill pathogens directly by …

Humans encode two inflammatory caspases that detect cytoplasmic LPS, caspase‐4 and
caspase‐5. When activated, these trigger pyroptotic cell death and caspase‐1‐dependent IL …

Antibiotics were once the golden bullet to constrain infectious bacteria. However, the rapid
and continuing emergence of antibiotic resistance (AR) among infectious microbial …

Reactive oxygen species (ROS) are critical components of the antimicrobial repertoire of
macrophages, yet the mechanisms by which ROS damage bacteria in the phagosome are …

Salmonella enterica infections result in diverse clinical manifestations. Typhoid fever,
caused by S. enterica serovar Typhi (S. Typhi) and S. Paratyphi A, is a bacteremic illness but …

Type III secretion systems (T3SSs) are complex bacterial structures that provide gram-
negative pathogens with a unique virulence mechanism enabling them to inject bacterial …

For intracellular pathogens such as Salmonellae, Mycobacteriae and Brucellae, infection
requires adaptation to the intracellular environment of the phagocytic cell. The transition …

Salmonella enterica serovar Typhimurium (S. Typhimurium) is a facultative intracellular
pathogen that causes disease in a variety of hosts. S. Typhimurium actively invade host cells …

Everything should be as simple as it can be, but not simpler.—Attributed to Albert Einstein
(1) IMPORTANCE Reactive oxygen species (ROS) are produced by host phagocytes and …