Autoimmune pre-disease
Approximately 5% of the world-wide population is affected by autoimmune diseases.
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …
Overall, autoimmune diseases are still difficult to treat, impose a high burden on patients …
[HTML][HTML] Immunoglobulin G glycosylation in aging and diseases
Abstract The Immunoglobulin G (IgG) glycome is well known for its heterogeneity and shows
a significant degree of variation within populations. IgG glycome composition is influenced …
a significant degree of variation within populations. IgG glycome composition is influenced …
How might contact with nature promote human health? Promising mechanisms and a possible central pathway
M Kuo - Frontiers in psychology, 2015 - frontiersin.org
How might contact with nature promote human health? Myriad studies have linked the two;
at this time the task of identifying the mechanisms underlying this link is paramount. This …
at this time the task of identifying the mechanisms underlying this link is paramount. This …
Mechanisms of autoantibody-induced pathology
RJ Ludwig, K Vanhoorelbeke, F Leypoldt… - Frontiers in …, 2017 - frontiersin.org
Autoantibodies are frequently observed in healthy individuals. In a minority of these
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
individuals, they lead to manifestation of autoimmune diseases, such as rheumatoid arthritis …
Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to destruction
VM Holers, MK Demoruelle, KA Kuhn… - Nature Reviews …, 2018 - nature.com
Individuals at high risk of developing seropositive rheumatoid arthritis (RA) can be identified
for translational research and disease prevention studies through the presence of highly …
for translational research and disease prevention studies through the presence of highly …
Mouse and human FcR effector functions
P Bruhns, F Jönsson - Immunological reviews, 2015 - Wiley Online Library
Mouse and human FcRs have been a major focus of attention not only of the scientific
community, through the cloning and characterization of novel receptors, and of the medical …
community, through the cloning and characterization of novel receptors, and of the medical …
Mast cell function: a new vision of an old cell
EZM da Silva, MC Jamur… - Journal of Histochemistry …, 2014 - journals.sagepub.com
Since first described by Paul Ehrlich in 1878, mast cells have been mostly viewed as
effectors of allergy. It has been only in the past two decades that mast cells have gained …
effectors of allergy. It has been only in the past two decades that mast cells have gained …
Imaging macrophages with nanoparticles
Nanomaterials have much to offer, not only in deciphering innate immune cell biology and
tracking cells, but also in advancing personalized clinical care by providing diagnostic and …
tracking cells, but also in advancing personalized clinical care by providing diagnostic and …
A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis
Although elevated levels of anti-citrullinated protein antibodies (ACPAs) are a hallmark of
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …
rheumatoid arthritis (RA), the in vivo functions of these antibodies remain unclear. Here, we …
Regulation of autoantibody activity by the IL-23–TH17 axis determines the onset of autoimmune disease
R Pfeifle, T Rothe, N Ipseiz, HU Scherer… - Nature …, 2017 - nature.com
The checkpoints and mechanisms that contribute to autoantibody-driven disease are as yet
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …
incompletely understood. Here we identified the axis of interleukin 23 (IL-23) and the TH17 …