Within blood vessels, endothelial cell–cell and cell–matrix adhesions are crucial to preserve
barrier function, and these adhesions are tightly controlled during vascular development …

Cardiovascular diseases and cancers are the leading causes of morbidity and mortality in
the world. MicroRNAs (miRNAs) are short non-coding RNAs that primarily repress target …

Abstract miRNAs act as oncogenes or tumor suppressors in a wide variety of human
cancers, including prostate cancer (PCa). We found a severe and consistent downregulation …

Mutations in the TP53 gene and microenvironmentally driven activation of hypoxia-inducible
factor-1 (HIF-1) typically occur in later stages of tumorigenesis. An ongoing challenge is the …

Wound healing is a basic biological process restoring the integrity of the skin. The role of
microRNAs during this process remains largely unexplored. By using an in vivo human skin …

P21-activated kinase 4 (PAK4) is a member of the p21-activated kinase (PAK) family.
Historically much of the attention has been directed towards founding family member PAK1 …

Breast cancer remains one of the leading causes of cancer mortality among women. It has
been proved that the onset of cancer depends on a very small pool of tumor cells with a …

Abstract Stromal interaction molecule 1 (Stim1) functions as a sensor of Ca 2+ within stores
and plays an essential role in the activation of store-operated Ca 2+ entry (SOCE). Although …

Abstract p21-activated kinase 4 (PAK4), a member of the serine-threonine kinase family,
was initially identified as a protein kinase that functions downstream of the Rho GTPases …

Single stem cells, including those in human epidermis, have a remarkable ability to
reconstitute tissues in vitro, but the cellular mechanisms that enable this are ill-defined. Here …