Staphylococcus aureus is a major human pathogen that causes a wide range of clinical
infections. It is a leading cause of bacteremia and infective endocarditis as well as …

Orthopaedic implants are highly susceptible to infection. The aims of treatment of infection
associated with internal fixation devices are fracture consolidation and prevention of chronic …

One or more of the authors of this paper have disclosed potential or pertinent conflicts of
interest, which may include receipt of payment, either direct or indirect, institutional support …

Orthopaedic and trauma device-related infection (ODRI) remains one of the major
complications in modern trauma and orthopaedic surgery. Despite best practice in medical …

Aims The aims of the study were to review and analyse the reported series of debridement,
antibiotics and implant retention (DAIR) in the management of infected total hip …

Rifampin has been used as an agent in combination therapy in orthopedic device-related
infections (ODRI) for almost three decades. The aim of this review is to provide data …

Rifamycins inhibit RNA polymerase of most bacterial genera. Rifampicin remains part of
combination therapy for treating tuberculosis (TB), and for treating Gram-positive prosthetic …

Periprosthetic joint infection (PJI) is a devastating complication after total joint arthroplasty,
occurring in approximately 1%-2% of all cases. With growing populations and increasing …

Outcomes from methicillin-resistant Staphylococcus aureus (MRSA) infections are relatively
poor, at least in part due to the limitations of vancomycin (the current standard treatment for …

The treatment of staphylococcal prosthetic joint infection (PJI) with debridement, antibiotics,
and retention of the implant (DAIR) often results in failure. An important evidence gap …