The transforming growth factor (TGF)-β signaling events are well known to control diverse
processes and numerous responses, such as cell proliferation, differentiation, apoptosis …

The biological action of androgens is mediated through the androgen receptor (AR).
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …

X-linked intellectual disability (XLID) is a clinically and genetically heterogeneous disorder.
During the past two decades in excess of 100 X-chromosome ID genes have been …

Specific modifications to histones are essential epigenetic markers—heritable changes in
gene expression that do not affect the DNA sequence. Methylation of lysine 9 in histone H3 …

Histone‐modifying enzymes play essential roles in physiological and aberrant gene
regulation. Since histone deacetylases (HDACs) are promising targets of cancer therapy, it …

A key event in the regulation of eukaryotic gene expression is the posttranslational
modification of nucleosomal histones, which converts regions of chromosomes into …

Since the identification of the first histone deacetylase (Taunton et al., Science 272, 408–
411), several new members have been isolated. They can loosely be separated into entities …

The LIM domain is a zinc finger structure that is present in several types of proteins,
including homeodomain transcription factors, kinases and proteins that consist of several …

Homeobox genes play fundamental roles in development. They can be subdivided into
several subfamilies, one of which is the LIM-homeobox subfamily. The primary structure of …

It is now becoming apparent that cross‐talk between two protein lysine modifications,
acetylation and ubiquitination, is a critical regulatory mechanism controlling vital cellular …