[HTML][HTML] Astrocyte reactivity influences amyloid-β effects on tau pathology in preclinical Alzheimer's disease
An unresolved question for the understanding of Alzheimer's disease (AD) pathophysiology
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
is why a significant percentage of amyloid-β (Aβ)-positive cognitively unimpaired (CU) …
Microglial activation and tau propagate jointly across Braak stages
Compelling experimental evidence suggests that microglial activation is involved in the
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
spread of tau tangles over the neocortex in Alzheimer's disease (AD). We tested the …
[HTML][HTML] Plasma p-tau231: a new biomarker for incipient Alzheimer's disease pathology
The quantification of phosphorylated tau in biofluids, either cerebrospinal fluid (CSF) or
plasma, has shown great promise in detecting Alzheimer's disease (AD) pathophysiology …
plasma, has shown great promise in detecting Alzheimer's disease (AD) pathophysiology …
The diagnostic and prognostic capabilities of plasma biomarkers in Alzheimer's disease
J Simrén, A Leuzy, TK Karikari, A Hye… - Alzheimer's & …, 2021 - Wiley Online Library
Introduction This study investigated the diagnostic and disease‐monitoring potential of
plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) …
plasma biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) …
Discriminative accuracy of [18F] flortaucipir positron emission tomography for Alzheimer disease vs other neurodegenerative disorders
Importance The positron emission tomography (PET) tracer [18 F] flortaucipir allows in vivo
quantification of paired helical filament tau, a core neuropathological feature of Alzheimer …
quantification of paired helical filament tau, a core neuropathological feature of Alzheimer …
18F-MK-6240 PET for early and late detection of neurofibrillary tangles
Braak stages of tau neurofibrillary tangle accumulation have been incorporated in the
criteria for the neuropathological diagnosis of Alzheimer's disease. It is expected that Braak …
criteria for the neuropathological diagnosis of Alzheimer's disease. It is expected that Braak …
[HTML][HTML] Cerebrospinal fluid p-tau231 as an early indicator of emerging pathology in Alzheimer's disease
Background Phosphorylated tau (p-tau) epitopes in cerebrospinal fluid (CSF) are accurate
biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are …
biomarkers for a pathological and clinical diagnosis of Alzheimer's disease (AD) and are …
Association of apolipoprotein E ε4 with medial temporal tau independent of amyloid-β
Importance Apolipoprotein E ε4 (APOEε4) is the single most important genetic risk factor for
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Alzheimer disease. WhileAPOEε4is associated with increased amyloid-β burden, its …
Mild behavioral impairment is associated with β‐amyloid but not tau or neurodegeneration in cognitively intact elderly individuals
FZ Lussier, TA Pascoal, M Chamoun… - Alzheimer's & …, 2020 - Wiley Online Library
Introduction Mild behavioral impairment (MBI) is characterized by the emergence of
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …
neuropsychiatric symptoms in elderly persons. Here, we examine the associations between …
Plasma tau/amyloid-β1–42 ratio predicts brain tau deposition and neurodegeneration in Alzheimer's disease
One of the hallmarks of Alzheimer's disease is abnormal deposition of tau proteins in the
brain. Although plasma tau has been proposed as a potential biomarker for Alzheimer's …
brain. Although plasma tau has been proposed as a potential biomarker for Alzheimer's …