Aucubin as a natural potential anti-acute hepatitis candidate: inhibitory potency and hepatoprotective mechanism
H Huang, YH Chang, J Xu, HY Ni, H Zhao, BW Zhai… - Phytomedicine, 2022 - Elsevier
Background Hepatic inflammation can substantially impact the development of acute
hepatitis. It is a pressing need to identify and exploit novel therapeutic targets as well as …
hepatitis. It is a pressing need to identify and exploit novel therapeutic targets as well as …
In silico exploration of metabolically active peptides as potential therapeutic agents against amyotrophic lateral sclerosis
TH Fatoki, S Chukwuejim, CC Udenigwe… - International Journal of …, 2023 - mdpi.com
Amyotrophic lateral sclerosis (ALS) is regarded as a fatal neurodegenerative disease that is
featured by progressive damage of the upper and lower motor neurons. To date, over 45 …
featured by progressive damage of the upper and lower motor neurons. To date, over 45 …
[HTML][HTML] Harmine and 7, 8-dihydroxyflavone synergistically suitable for amyotrophic lateral sclerosis management: An in silico study
T Fatoki, S Chukwuejim, O Ibraheem, C Oke… - Research Results in …, 2022 - cyberleninka.ru
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease
characterized by progressive degeneration of both upper and lower motor neurons, resulting …
characterized by progressive degeneration of both upper and lower motor neurons, resulting …
[PDF][PDF] Friedelin Could Moderately Modulate Human Carbonic Anhydrases: An in Silico Study
Friedelin (friedelan-3-one or 3-oxofriedelane), a plant metabolite, is a pentacyclic
triterpenoid with pharmacological properties that include anti-inflammatory, antioxidant …
triterpenoid with pharmacological properties that include anti-inflammatory, antioxidant …
Predictive potential of BCS and pharmacokinetic parameters on study outcome: analysis of 198 in vivo bioequivalence studies
D Krajcar, I Grabnar, R Jereb, I Legen… - European journal of drug …, 2023 - Springer
Abstract Background and Objectives Understanding predictive potential of parameters to
perform early bioequivalence (BE) risk assessment is crucial for good planning and risk …
perform early bioequivalence (BE) risk assessment is crucial for good planning and risk …
In silico investigation of molecular targets, pharmacokinetics, and biological activities of chicken egg ovalbumin protein hydrolysates
Food-derived bioactive peptides are promising ingredients for developing functional foods
and nutraceuticals due to their putative safety, low cost, and multiple health benefits …
and nutraceuticals due to their putative safety, low cost, and multiple health benefits …
Molecular docking, MMGBSA, and ADMET studies of phytoconstituents of Ocimum gratissimum on multiple breast cancer targets
O. gratissimum is one of the most common medicinal plants in every community in Nigeria.
This plant has been presumed to be useful in the management of diseases including breast …
This plant has been presumed to be useful in the management of diseases including breast …
ADME, Molecular Targets, Docking and Dynamic Simulation Studies of Phytoconstituents of Cymbopogon citratus (DC.)
Abstract Cymbopogon citratus (DC) Stapf., is utilized in both culinary and medicinal contexts,
wherein its extracts demonstrate a range of therapeutic properties, including antidiabetic …
wherein its extracts demonstrate a range of therapeutic properties, including antidiabetic …
[PDF][PDF] Harmine and 7, 8-Dihydroxyflavone Synergistically Suitable for Amyotrophic Lateral Sclerosis Management: An in Silico Study. Research Results in …
T Fatoki, S Chukwuejim, O Ibraheem, C Oke, B Ejimadu… - 2022 - academia.edu
Introduction: Amyotrophic lateral sclerosis (ALS) is a fatal neurological disease
characterized by progressive degeneration of both upper and lower motor neurons, resulting …
characterized by progressive degeneration of both upper and lower motor neurons, resulting …
Rational virtual screening, ADME, and molecular simulation studies of potential inhibitors of human superoxide dismutase 1 in a dysfunctional antioxidant system
Abstract Superoxide dismutase 1 (SOD1), a copper-dependent enzyme, facilitates the
conversion of superoxide anions into hydrogen peroxide and oxygen, thereby regulating …
conversion of superoxide anions into hydrogen peroxide and oxygen, thereby regulating …