Surgical site infections (SSIs) have played a major role in the evolution of medical care
throughout history. Wound complications contributed significantly to the historical surgical …

Daptomycin is a lipopeptide antimicrobial with in vitro bactericidal activity against Gram-
positive bacteria that was first approved for clinical use in 2004 in the United States. Since …

It is important to realize that guidelines cannot always account for individual variation among
patients. They are not intended to supplant physician judgment with respect to particular …

To clarify whether apoptosis is involved in the injury processes induced by autoantibody
against cardiac β1-adrenoceptor, we investigated the biological and apoptotic effects of …

Abstract (See the article by Patel et al, on pages 969–974.) Background. High rates of
vancomycin failure in methicillin-resistant Staphylococcus aureus (MRSA) infections have …

Vancomycin is one of the older antibiotics that has been now in clinical use close to 60
years. Earlier on, vancomycin was associated with many side effects including vestibular …

The introduction of antimicrobial drugs in medicine gave hope for a future in which all
infectious diseases could be controlled. Decades later it appears certain this will not be the …

ABSTRACT A ratio of the vancomycin area under the concentration-time curve to the MIC
(AUC/MIC) of≥ 400 has been associated with clinical success when treating …

Methods Clinical practice guidelines for TDM of VCM were reviewed by a practice guideline
committee that consisted of 18 experts in TDM convened from the JSC and the JSTDM. The …

Vancomycin has been used as the last resort in the clinical treatment of serious
Staphylococcus aureus infections. Vancomycin-intermediate S. aureus (VISA) was …