Recent advances of oncolytic virus in cancer therapy
M Mondal, J Guo, P He, D Zhou - Human vaccines & …, 2020 - Taylor & Francis
Oncolytic viruses have been taking the front stage in biological therapy for cancer recently.
The first and most potent virus to be used in oncolytic virotherapy is human adenovirus …
The first and most potent virus to be used in oncolytic virotherapy is human adenovirus …
Virus-mediated cell-cell fusion
Cell-cell fusion between eukaryotic cells is a general process involved in many
physiological and pathological conditions, including infections by bacteria, parasites, and …
physiological and pathological conditions, including infections by bacteria, parasites, and …
Herpes simplex virus glycoproteins gH/gL and gB bind Toll-like receptor 2, and soluble gH/gL is sufficient to activate NF-κB
V Leoni, T Gianni, S Salvioli… - Journal of …, 2012 - Am Soc Microbiol
ABSTRACT A number of sentinels sense incoming herpes simplex virus (HSV) virions and
initiate an immediate innate response. The first line of defense at the cell surface is TLR2 …
initiate an immediate innate response. The first line of defense at the cell surface is TLR2 …
Genomic signature of the natural oncolytic herpes simplex virus HF10 and its therapeutic role in preclinical and clinical trials
IR Eissa, Y Naoe, I Bustos-Villalobos, T Ichinose… - Frontiers in …, 2017 - frontiersin.org
Oncolytic viruses (OVs) are opening new possibilities in cancer therapy with their unique
mechanism of selective replication within tumor cells and triggering of antitumor immune …
mechanism of selective replication within tumor cells and triggering of antitumor immune …
The soluble ectodomain of herpes simplex virus gD contains a membrane-proximal pro-fusion domain and suffices to mediate virus entry
Entry of herpes simplex virus (HSV) 1 into cells requires the interaction of HSV gD with
herpesvirus entry mediator or nectin1 receptors, and fusion with cell membrane mediated by …
herpesvirus entry mediator or nectin1 receptors, and fusion with cell membrane mediated by …
αvβ6-and αvβ8-integrins serve as interchangeable receptors for HSV gH/gL to promote endocytosis and activation of membrane fusion
T Gianni, S Salvioli, LS Chesnokova… - PLoS …, 2013 - journals.plos.org
Herpes simplex virus (HSV)-and herpesviruses in general-encode for a multipartite
entry/fusion apparatus. In HSV it consists of the HSV-specific glycoprotein D (gD), and three …
entry/fusion apparatus. In HSV it consists of the HSV-specific glycoprotein D (gD), and three …
Herpes simplex virus Membrane Fusion
DJ Weed, AV Nicola - Cell biology of herpes viruses, 2017 - Springer
Herpes simplex virus mediates multiple distinct fusion events during infection. HSV entry is
initiated by fusion of the viral envelope with either the limiting membrane of a host cell …
initiated by fusion of the viral envelope with either the limiting membrane of a host cell …
Herpes simplex virus gD forms distinct complexes with fusion executors gB and gH/gL in part through the C-terminal profusion domain
T Gianni, M Amasio, G Campadelli-Fiume - Journal of Biological Chemistry, 2009 - ASBMB
Herpes simplex virus entry into cells requires a multipartite fusion apparatus made of
glycoprotein D (gD), gB, and heterodimer gH/gL. gD serves as a receptor-binding …
glycoprotein D (gD), gB, and heterodimer gH/gL. gD serves as a receptor-binding …
“Non-essential” proteins of HSV-1 with essential roles in vivo: a comprehensive review
C Dogrammatzis, H Waisner, M Kalamvoki - Viruses, 2020 - mdpi.com
Viruses encode for structural proteins that participate in virion formation and include capsid
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …
and envelope proteins. In addition, viruses encode for an array of non-structural accessory …
The herpes simplex virus type 1 UL20 protein modulates membrane fusion events during cytoplasmic virion morphogenesis and virus-induced cell fusion
The herpes simplex virus type 1 (HSV-1) UL20 protein is an important determinant for virion
morphogenesis and virus-induced cell fusion. A precise deletion of the UL20 gene in the …
morphogenesis and virus-induced cell fusion. A precise deletion of the UL20 gene in the …