The volume of published biomedical research, and therefore the underlying biomedical
knowledge base, is expanding at an increasing rate. Among the tools that can aid …

In biomedical research, the amount of experimental data and published scientific information
is overwhelming and ever increasing, which may inhibit rather than stimulate scientific …

Transcription factor (TF) binding site (TFBS) models are crucial for computational
reconstruction of transcription regulatory networks. In existing repositories, a TF often has …

Genome-wide techniques such as microarray analysis, Serial Analysis of Gene Expression
(SAGE), Massively Parallel Signature Sequencing (MPSS), linkage analysis and association …

Background There are now a multitude of articles published in a diversity of journals
providing information about genes, proteins, pathways, and diseases. Each article …

Background Advances in sequencing technology over the past decade have resulted in an
abundance of sequenced proteins whose function is yet unknown. As such, computational …

Prostate cancer (PC) is one of the most commonly diagnosed cancers in men. PC is
relatively difficult to diagnose due to a lack of clear early symptoms. Extensive research of …

Redox control is lost when the antioxidant defense system cannot remove abnormally high
concentrations of signaling molecules, such as reactive oxygen species (ROS). Chronically …

The current era of large-scale biology is characterized by a fast-paced growth in the number
of sequenced genomes and, consequently, by a multitude of identified proteins whose …

Background Fetal alcohol syndrome (FAS) is a serious global health problem and is
observed at high frequencies in certain South African communities. Although in utero …