Sepsis is a persistent systemic inflammatory condition involving multiple organ failures
resulting from a dysregulated immune response to infection, and one of the hallmarks of …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Vessel sprouting by migrating tip and proliferating stalk endothelial cells (ECs) is controlled
by genetic signals (such as Notch), but it is unknown whether metabolism also regulates this …

There is a growing interest in developing microphysiological systems that can be used to
model both normal and pathological human organs in vitro. This “organs-on-chips” …

In contrast to the general belief, endothelial cell (EC) metabolism has recently been
identified as a driver rather than a bystander effect of angiogenesis in health and disease …

Angiogenesis has traditionally been viewed from the perspective of how endothelial cells
(ECs) coordinate migration and proliferation in response to growth factor activation to form …

Endothelial cells (ECs) are quiescent for years but can plastically switch to angiogenesis.
Vascular sprouting relies on the coordinated activity of migrating tip cells at the forefront and …

Endothelial cells (ECs) require glycolysis for proliferation and migration during
angiogenesis; however, the necessity for the mitochondrial respiratory chain during …

Cardiovascular disease (CVD) has been the leading cause of death for many decades,
highlighting the importance of new research and treatments in the field. The role of hypoxia …

Endothelial cell (EC) metabolism has lately emerged as a novel and promising therapeutic
target to block vascular dysregulation associated with diseases like cancer and blinding eye …