[HTML][HTML] Olfactory evaluation in Alzheimer's disease model mice

J Zhang, Z Zhao, S Sun, J Li, Y Wang, J Dong, S Yang… - Brain Sciences, 2022 - mdpi.com
Olfactory dysfunction is considered a pre-cognitive biomarker of Alzheimer's disease (AD).
Because the olfactory system is highly conserved across species, mouse models …

[HTML][HTML] Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer's disease

KC Tsui, J Roy, SC Chau, KH Wong, L Shi… - Frontiers in Aging …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. Although previous studies
have selectively investigated the localization of amyloid-beta (Aβ) deposition in certain brain …

Olfactory Dysfunction and Alzheimer's Disease: A Review

AMR McLaren, MD Kawaja - Journal of Alzheimer's Disease, 2024 - content.iospress.com
Alzheimer's disease is the most common cause of dementia, and it is one of the leading
causes of death globally. Identification and validation of biomarkers that herald the onset …

Comparison of olfactory cleft width and volumes in patients with COVID-19 anosmia and COVID-19 cases without anosmia

DE Tekcan Sanli, A Altundag, D Yıldırım… - ORL, 2022 - karger.com
Introduction: The aim of this study was to assess the relationship between olfactory cleft
width/volume and COVID-19-related anosmia. Methods: This study consisted of PCR-proven …

[HTML][HTML] Olfactory signatures in the food finding test in mice with normal and Alzheimer's disease-pathological aging with special concerns on the effects of social …

D Marín-Pardo, L Giménez-Llort - Frontiers in Neuroscience, 2021 - frontiersin.org
The temporal course and the severity of the involution of sensory systems through aging can
be critical since they ensure the ability to perceive and recognize the world. In older people …

[HTML][HTML] Investigation of anxiety-and depressive-like symptoms in 4-and 8-month-old male triple transgenic mouse models of Alzheimer's disease

D Várkonyi, B Török, E Sipos, CL Fazekas… - International Journal of …, 2022 - mdpi.com
Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the most
common form of dementia. Approximately 50% of AD patients show anxiety and depressive …

Amyloid β oligomers disrupt piriform cortical output via a serotonergic pathway

X Wang, M Hu, Q Xie, C Geng, C Jin, W Ren, J Fan… - Neurobiology of …, 2023 - Elsevier
Although olfactory deficits have been found in patients with early-stage Alzheimer's disease
(AD), the underlying mechanisms remain unclear. Here we investigated whether and how …

[HTML][HTML] Temporal Appearance of Enhanced Innate Anxiety in Alzheimer Model Mice

A Szabó, S Farkas, C Fazekas, P Correia, T Chaves… - Biomedicines, 2023 - mdpi.com
The prevalence of Alzheimer's disorder (AD) is increasing worldwide, and the co-morbid
anxiety is an important, albeit often neglected problem, which might appear early during …

[HTML][HTML] Gene expression analysis of the endocannabinoid system in presymptomatic APP/PS1 mice

L Vidal-Palencia, C Ramon-Duaso… - Frontiers in …, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common type of dementia and neurodegeneration. The
actual cause of AD progression is still unknown and no curative treatment is available …

A signal detection analysis of olfactory learning in 12-month-old 5xFAD mice

KM Roddick, E Fertan, HM Schellinck… - Journal of Alzheimer's …, 2022 - content.iospress.com
Although Alzheimer's disease is most often studied in terms of memory impairments,
olfactory dysfunction begins in the early stages. We tested olfactory learning, sensitivity, and …