Therapeutic strategies for COVID-19: progress and lessons learned

G Li, R Hilgenfeld, R Whitley, E De Clercq - Nature Reviews Drug …, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic has stimulated tremendous
efforts to develop therapeutic strategies that target severe acute respiratory syndrome …

Current landscape of methods to evaluate antimicrobial activity of natural extracts

R Gonzalez-Pastor, SE Carrera-Pacheco… - Molecules, 2023 - mdpi.com
Natural extracts have been and continue to be used to treat a wide range of medical
conditions, from infectious diseases to cancer, based on their convenience and therapeutic …

Green and efficient one-pot three-component synthesis of novel drug-like furo [2, 3-d] pyrimidines as potential active site inhibitors and putative allosteric hotspots …

H Mousavi, B Zeynizadeh, M Rimaz - Bioorganic Chemistry, 2023 - Elsevier
In this paper, an environmentally benign, convenient, and efficient one-pot three-component
reaction has been developed for the regioselective synthesis of novel 5-aroyl (or …

Fermentation, functional analysis, and biological activities of turmeric kombucha

MI Khazi, F Liaqat, X Liu, Y Yan… - Journal of the Science of …, 2024 - Wiley Online Library
BACKGROUND Kombucha is a popular fermented drink with therapeutic benefits. The
present study aimed to examine the fermentation of turmeric‐infused kombucha and …

Inhibitory effect of phytochemicals towards SARS-CoV-2 papain like protease (PLpro) proteolytic and deubiquitinase activity

A Kawall, DSM Lewis, A Sharma, K Chavada… - Frontiers in …, 2023 - frontiersin.org
Recent studies have shown that RNA-dependent RNA polymerase (RdRp), 3-chymotrypsin-
like protease (3CLpro), and papain-like protease (PLpro) are necessary for SARS-CoV-2 …

European Black elderberry fruit extract inhibits replication of SARS-CoV-2 in vitro

C Setz, M Fröba, M Große, P Rauch, J Auth… - Nutraceuticals, 2023 - mdpi.com
Coronavirus disease-19 (COVID-19) is still affecting the lives of people round the globe and
remains a major public health threat. The emergence of new variants more efficiently …

Phytochemistry and therapeutic potential of the genus Asphodelus L.: an update

L Nahar, A Al Groshi, L Thangavelu, F Ismail… - Phytochemistry …, 2024 - Springer
The genus Asphodelus L.(family: Asphodelaceae) comprises ca. 20 hardy herbaceous,
perennial flowering plant species, and is native to Africa, the Indian subcontinent, the …

Recent Advances on Targeting Proteases for Antiviral Development

PHO Borges, SB Ferreira, FP Silva Jr - Viruses, 2024 - mdpi.com
Viral proteases are an important target for drug development, since they can modulate vital
pathways in viral replication, maturation, assembly and cell entry. With the (re) appearance …

Biopolymer-based coating materials for antiviral and antifungal applications: Recent advances in formulations and characterization

ZT Juthi, M Jabeen, MR Islam, P Biswas… - Chemical Engineering …, 2024 - Elsevier
The increased severity of viral infections, particularly due to the emergence of more severe
SARS-CoV-2 variants, has resonated with the urgency of developing sustainable and …

Structural review of SARS-CoV-2 antiviral targets

W Cui, Y Duan, Y Gao, W Wang, H Yang - Structure, 2024 - cell.com
Summary The coronavirus disease 2019 (COVID-19), the disease caused by the severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents the most disastrous …