Sphingolipids are a family of lipids that are critical to cell function and survival. Much of the
recent work done on sphingolipids has been performed by a closely-knit family of …

Ceramides, the principal building blocks of all sphingolipids, have attracted the attention of
many scientists around the world interested in developing treatments for cystic fibrosis, the …

Maintenance of metabolic homeostasis requires adaption of gene regulation to the cellular
energy state via transcriptional regulators. Here, we identify a role of ceramide synthase …

Lipotoxicity arises from the accumulation of lipid intermediates in non-adipose tissue,
precipitating cellular dysfunction and death. Ceramide, a toxic byproduct of excessive free …

Abstract Ceramide synthase 2 (CerS2) catalyzes the synthesis of dihydroceramides from
dihydrosphingosine and very long fatty acyl (C22–C24)-CoAs. CerS2-deficient (gene trap) …

The replacement of two consecutive histidine residues by alanine residues in the catalytic
center of ceramide synthase 2 in a new transgenic mouse mutant (CerS2 H/A) leads to …

Mycotoxins that contaminate grain can cause the devaluation of agricultural products and
create health risks for the consumer. Fumonisins are one such mycotoxin. Produced …

Individuals with type 2 diabetes display metabolic abnormalities, such as hyperglycemia,
increased free fatty acids, insulin resistance, and altered ceramide levels, that contribute to …

Ceramide is known to trigger apoptosis of nucleated cells and eryptosis of erythrocytes.
Eryptosis is characterized by cell shrinkage and cell membrane scrambling with …

Drosophila Ceramide Synthase (CerS) Schlank regulates both ceramide synthesis and fat
metabolism. Schlank contains a catalytic lag1p motif and, like many CerS in other species, a …