Compartmentalization is a ubiquitous feature of cellular function. In the nucleus, early
observations revealed a non-random spatial organization of the genome with a large-scale …

Transcriptional regulation in metazoans occurs through long-range genomic contacts
between enhancers and promoters, and most genes are transcribed in episodic" bursts" of …

Gene expression in mammalian cells is highly variable and episodic, resulting in a series of
discontinuous bursts of mRNAs. A challenge is to understand how static promoter …

Nearly identical cells can exhibit substantially different responses to the same stimulus that
causes phenotype diversity. Such interplay between phenotype diversity and the …

Fractional killing, which is a significant impediment to successful chemotherapy, is observed
even in a population of genetically identical cancer cells exposed to apoptosis-inducing …

Many biological processes including important intracellular processes are governed by
biochemical reaction networks. Usually, these reaction systems operate far from …

While the timing of intracellular events is essential for many cellular processes, gene
expression inside a single cell can exhibit substantial cell-to-cell variability, raising the …

Gene expression has been extensively studied in terms of Markov processes, but its
stochastic mechanisms including how noisy sources contribute to expression levels still …

The origin of an ordered genetic response of a complex and noisy biological cell is
intimately related to the detailed mechanism of protein–DNA interactions present in a wide …

Transcriptional regulation occurs through genomic contacts between enhancers and their
cognate promoters, and most genes are transcribed in a bursty fashion. To understand the …